Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group  

作　　者：JING Jianying WANG Dan JIAO Yi WANG Xiaofeng WEN Hao LIN Renyong JIN Jianzhong JIN Li 

机构地区：[1]Department of Biology,School of Environment and Chemical Engineering,Luoyang University,Luoyang 471000,China [2]Institute of Genetics,School of Life Sciences,Fudan University,Shanghai 200433,China [3]Department of Biochemical and Molecular Biology,Xinjiang Medical University,Urumqi 830054,China [4]Central Laboratory,the First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China

出　　处：《Frontiers of Medicine》2007年第2期230-233,共4页医学前沿（英文版）

基　　金：The study was supported by the National Natural Science Foundation of China(Grant No.30500291).

摘　　要：The relationship between the tenth exon C825T of G-protein β3 subunit(GNB3)genetic polymorphism and hypertension in the Uygur population of China was investigated.A nested case-control study(n=738)was carried out.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive(HT)and 384 normotensive(NT)Uygur subjects.The distributions of GNB3 C825T genotypes were CC(27.2%),TT(42.9%),and CT(29.9%)in the hypertensive subjects and CC(27.7%),TT(42.4%),CT(29.9%)in the normotensive subjects.There were no significant differences in the genotype distributions between the two groups(χ^(2)=0.0262 P=0.99).The T allele was 51.4%in hypertensive subjects and 51.2%in normotensive subjects,which,between the two groups,was not a significant difference(χ^(2)=0.0016 P=0.97).Further analysis shows that there is no association between C825T genotypes and age,body mass index(BMI),Glucose(GLU),Triglyceride(TG),Cholesterol(CHO),systolic blood pressure(SBP)and diastolic blood pressure(DBP).No evidence was found to suggest an association between GNB3 C825T polymorphism and hypertension in the Uygur population of China.

关 键 词：UYGUR HYPERTENSION G protein POLYMORPHISM 

分 类 号：R54[医药卫生—心血管疾病]