胰岛素样生长因子在肥胖 发生发展中的作用  

The Role of Insulin-Like Growth Factor in the Development of Obesity

作　　者：丁凤 张炜真[2] 尹悦 DING Feng;ZHANG Wei-Zhen;YIN Yue(The Third Hospital of Peking University;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Health Science Center,Peking University;Department of Pharmacology,School of Basic Medical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院 [2]北京大学基础医学院生理与病理生理学系 [3]北京大学基础医学院药理学系,北京100191

出　　处：《生理科学进展》2023年第4期297-303,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金(81730020,81930015,82070592,82270610);中国科学技术协会青年人才托举工程(YESS20200034)资助课题。

摘　　要：近年来,肥胖的发病率逐年上升,给人类健康和社会经济带来严重负担。胰岛素样生长因子(insulin-like growth factor)是一种化学结构上与胰岛素高度同源的多肽物质,参与机体多种物质的代谢,与肥胖的发生发展密切相关。本文将概述胰岛素样生长因子轴的组成,重点综述胰岛素样生长因子在肥胖发生发展中的作用及其相关机制,为肥胖的防治提供新的思路和策略。In recent years,the incidence of obesity has been increasing,bringing a serious burden to human health and the social economy.Insulin-like growth factor(IGF)is a polypeptide highly homologous with insulin in structure,which participates in the metabolism of various substances in the body and is closely related to the occurrence and development of obesity.This article outlines the composition of the IGF axis and focuses on the role of IGF in the development of obesity as well as the underlying mechanisms,aiming to provide new ideas and strategies for the prevention and treatment of obesity.

关 键 词：胰岛素样生长因子 IGF-1 IGF-2 肥胖 

分 类 号：R335[医药卫生—人体生理学]