食管癌的CT及MRI影像表现与血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4表达的相关性及其诊断价值分析  

Correlation Between CT and MRI Findings of Esophageal Carcinoma and The Expression of Serum CEA,Cyfra21-1,SCC-Ag,CA19-9,CA72-4 and Its Diagnostic Value

作　　者：陈志林[1] 徐秋贞[1] 陶禹 张明府 肖勇 Chen Zhi-lin;Xu Qiu-zhen;Tao Yu;Zhang Ming-fu;Xiao Yong(Department of Imaging,Jiangbei District of Zhongda Hospital Affiliated to Southeast University,Nanjing 210044,Jiangsu Province,China;Department of General Surgery,Jiangbei District of Zhongda Hospital Affiliated to Southeast University,Nanjing 210044,Jiangsu Province,China;Department of Imaging,Yancheng First People's Hospital,Yancheng 224000,Jiangsu Province,China)

机构地区：[1]东南大学附属中大医院江北院区影像科,江苏南京210044 [2]东南大学附属中大医院江北院区普外科,江苏南京210044 [3]盐城市第一人民医院影像科,江苏盐城224000

出　　处：《中国CT和MRI杂志》2023年第8期88-91,共4页Chinese Journal of CT and MRI

基　　金：江苏省卫生健康委医学科研项目(MSXM2021154)。

摘　　要：目的探讨食管癌的电子计算机断层扫描仪器(CT)及磁共振成像(MRI)影像表现与血清癌胚抗原(CEA)、细胞角化素蛋白19片段(Cyfra21-1)、鳞状细胞癌相关抗原(SCC-Ag)、糖类抗原19-9(CA19-9)、糖类抗原72-4(CA72-4)表达的相关性及其诊断价值分析。方法将我院2019年4月至2022年4月纳入的64例食管癌患者作为观察组,另外,同期56例在我院进行健康体检者作为对照组。观察食管癌的CT及MRI的影像表现,比较两组的血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4水平,分析食管癌的CT及MRI影像表现与血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4表达的关系及相关性,进一步探讨食管癌的CT及MRI影像表现与血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4单项及联合检测在食管癌中的诊断结果、诊断效能。结果CT检查显示:食管壁结节样病变,向腔内突出,管腔偏心性狭窄,管腔呈点状改变。食管壁环形增厚,管腔向心性狭窄,邻近气管隆突下淋巴结转移。MRI检查显示:管壁明显增厚,管腔狭窄,邻近纵隔淋巴结肿大;病变于T1WI显示为等信号,T2WI显示为较高信号,DWI显示为明显高信号,增强扫描出现明显强化。与对照组比较,观察组的血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4水平显著增高(P<0.05)。病灶>3cm、肿瘤边缘粗糙、有淋巴结转移的食管癌患者的血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4水平高于病灶≤3cm、肿瘤边缘光滑、无淋巴结转移的食管癌患者(P<0.05);肿瘤位置在食管中段的食管癌患者的血清CEA、Cyfra21-1、SCC-Ag、CA19-9、CA72-4水平高于肿瘤位置在食管上段、食管下段的食管癌患者(P<0.05)。经Pearson相关分析显示,食管癌肿瘤边缘与血清CA19-9、CA72-4水平呈正相关(P<0.05);食管癌淋巴结转移与血清CEA、CA19-9、CA72-4水平呈正相关(P<0.05);食管癌肿瘤位置与血清CEA、CA72-4水平呈正相关(P<0.05)。经ROC曲线结果表明,食管癌的CT及MRI影像表现�Objective To investigate the correlation between CT and magnetic resonance imaging(MRI)manifestations of esophageal cancer and the expression of serum carcinoembryonic antigen(CEA),cytokeratin 19 fragment(Cyfra21-1),squamous cell carcinoma associated antigen(SCC-Ag),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 72-4(CA72-4)and their diagnostic value.Methods 64 patients with esophageal cancer who were included in our hospital from April 2019 to April 2022 were taken as the observation group,and 56 patients who underwent physical examination in our hospital at the same time were taken as the control group.To observe the imaging manifestations of CT and MRI,compare the levels of serum CEA,Cyfra21-1,SCC-Ag,CA19-9,CA72-4 between the two groups,analyze the relationship and correlation between CT and MRI imaging characteristics of esophageal cancer patients and the levels of serum CEA,Cyfra21-1,SCC-Ag,CA19-9,CA72-4,and further explore the diagnostic results and diagnostic efficacy of CT and MRI and serum CEA,Cyfra21-1,SCC-Ag,CA19-9,CA72-4 in esophageal cancer.Results CT examination showed that the nodular lesions of the esophageal wall protruded into the lumen,the lumen was eccentric stenosis,and the lumen was dotted.The esophageal wall is annular thickened,the lumen is centripetal narrow,and lymph nodes adjacent to the tracheal carina metastasize.MRI examination showed that the wall of the tube was obviously thickened,the lumen was narrow,and the adjacent mediastinal lymph nodes were enlarged;The lesions showed equal signal on T1WI,high signal on T2WI,high signal on DWI,and obvious enhancement on enhanced scan.Compared with the control group,the levels of serum CEA,Cyfra21-1,SCC-Ag,CA19-9 and CA72-4 in the observation group were significantly higher(P<0.05).The serum CEA,Cyfra21-1,SCC-Ag,CA19-9,CA72-4 levels in patients with esophageal cancer with lesions>3cm,rough tumor margins,and lymph node metastasis were higher than those in patients with esophageal cancer with lesions≤3 cm,smooth tumor margins,and no l

关 键 词：食管癌 CT MRI CEA CYFRA21-1 SCC-AG CA19-9 CA72-4 诊断价值 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.1[医药卫生—诊断学]