枇杷清肺饮加减联合壬二酸凝胶治疗肺经风热型轻中度寻常痤疮的疗效观察  

Clinical Observation Of Modified Pipa Qingfei Decoction Combined With Azelaic Acid Gel In Treating Mild To Moderate Acne Vulgaris With Syndrome Of Wind-Heat In Lung Meridian

作　　者：胡君 毕鸣晔 黄海峰 郝利明 HU Jun;BI Ming-ye;HUANG Hai-feng;HAO Li-ming(The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi People's Hospital,Wuxi Medical Center,Nanjing Medical University,Jiangsu Province,214023,China)

机构地区：[1]南京医科大学无锡医学中心、无锡市人民医院、南京医科大学附属无锡人民医院,江苏无锡214023

出　　处：《中国医疗美容》2023年第7期40-43,共4页China Medical Cosmetology

摘　　要：目的观察枇杷清肺饮加减联合壬二酸凝胶治疗肺经风热型轻中度寻常痤疮的临床疗效。方法将87名中医辨证为肺经风热轻中度寻常痤疮的患者,随机分为三组:A组30例,枇杷清肺饮加减联合壬二酸凝胶治疗;B组28例,单用枇杷清肺饮加减治疗;C组29例,单用壬二酸凝胶治疗;治疗结束后8周进行疗效评估。结果经过8周的治疗后,A组的总有效率86.67%,B组的总有效率64.29%,C组的总有效率为55.17%,三组比较,疗效差异有统计学意义(P<0.05)。三组皮损数均较治疗前下降,A组在完成治疗后皮损数目更低(P<0.05)。A组与B组中医证候疗效的有效率分别为70%,67.86%,两者差异无统计学意义(P>0.05)。在治疗痤疮炎症后色素沉着方面,三组的有效率分别为83.33%,39.29%,82.76%,A组、C组疗效显著优于B组(P<0.05)。三组均未出现严重的不良反应。结论枇杷清肺饮加减联合壬二酸凝胶治疗肺经风热型轻中度寻常痤疮安全有效,临床值得推广使用。Objective To evaluate the efficacy of modified Pipa Qingfei decoction combined with azelaic acid gel in treating mild to moderate acne vulgaris with syndrome of wind-heat in lung meridian.Methods 87 patients with mild to moderate acne with syndrome of wind-heat in lung meridian according to TCM syndrome differentiation were randomly divided into three groups.30 patients in group A were treated with modified Pipa Qingfei decoction combined with azelaic acid gel,28 patients in group B were treated with modified Pipa Qingfei decoction only,and at the same time,29 patients in group C were treated with azelaic acid gel only.Efficacy was evaluated at the baseline and at the end of the treatment of 8 weeks.Results After the treatment of 8 weeks,the total effective rate of group A was 86.67%,which was much higher than that of group B(64.29%)and group C(55.17%)and there were significant differences among the three groups(P<0.05).Meanwhile,the number of the lesions in all three groups significantly decreased after 8 weeks(P<0.05),and which was lower in group A after the treatment(P<0.05).The effective rates of the TCM syndrome in group A and group B were 70%,67.86%respectively,and there was no significant difference between the two groups(P>0.05).Furthermore,in treating post-inflflammatory hyperpigmentation after acne,83.33%patients in group A,39.29%patients in group B and 82.76%patients in group C received effective results,which showed that group A and group C performed significantly better than group B(P<0.05).No serious adverse reactions were observed in three groups.Conclusion The treatment of mild to moderate acne with syndrome of windheat in lung meridian by using modified Pipa Qingfei decoction combined with azelaic acid gel was safe and effective,thus worthy of a clinical popularization and application.

关 键 词：枇杷清肺饮加减 壬二酸 肺经风热 痤疮 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]