GC法同时测定壮骨麝香止痛凝胶贴膏中5种挥发性成分  

Simultaneous determination of five volatile constituents in Zhuanggu Shexiang Zhitong Gel Paste

作　　者：汤燕[1] 朱宁[2] 沈立[1] 崔红梅[1] 罗恒[1] TANG Yan;ZHU Ning;SHEN Li;CUI Hong-mei;LUO Heng(Center of Instrumental Analysis,Sichuan Provincial Academy of Chinese Medicine Sciences,Chengdu 610041,China;Institute of Traditional Chinese Medicine,Sichuan Provincial Academy of Chinese Medicine Sciences,Chengdu 610041,China)

机构地区：[1]四川省中医药科学院分析测试中心,四川成都610041 [2]四川省中医药科学院中药药学研究所,四川成都610041

出　　处：《中成药》2023年第8期2505-2508,共4页Chinese Traditional Patent Medicine

基　　金：四川省科技厅省级科研院所基本科研业务专项项目(A-2021N-17)。

摘　　要：目的建立GC法同时测定壮骨麝香止痛凝胶贴膏中薄荷脑、樟脑、龙脑、异龙脑、水杨酸甲酯的含量。方法该药物乙酸乙酯提取液的分析采用DB-WAX色谱柱(30 m×0.25 mm×0.50μm);载气氮气;FID检测器,温度240℃;分流比5∶1;程序升温。结果5种挥发性成分在各自范围内线性关系良好(R^(2)≥0.9997),平均加样回收率97.40%~99.88%,RSD 1.6%~4.0%。结论该方法准确、稳定、可靠,可用于壮骨麝香止痛凝胶贴膏的质量控制。AIM To establish a GC method for the simultaneous content determination of L-menthol,camphor,borneol,isoborneol and methyl salicylate in Zhuanggu Shexiang Zhitong Gel Paste.METHODS The analysis of ethyl acetate extract of this drug was performed on DB-WAX column(30 m×0.25 mm×0.50μm),the carrier gas was nitrogen,FID detector temperature was 240℃,and the split ratio was 5∶1 in temperature programming.RESULTS Five volatile constituents showed good linear relationships within their own ranges(R^(2)≥0.9997),whose average recoveries were 97.40%-99.88%with the RSDs of 1.6%-4.0%.CONCLUSION This accurate,stable and reliable method can be used for the quality control of Zhuanggu Shexiang Zhitong Gel Paste.

关 键 词：壮骨麝香止痛凝胶贴膏 薄荷脑 樟脑 龙脑 异龙脑 水杨酸甲酯 GC 

分 类 号：R927.2[医药卫生—药学]