小钻化学成分的研究(Ⅱ)  

Chemical constituents from Kadsura longipedunculata(Ⅱ)

作　　者：唐炳兰[1] 覃朗[2] 蒋莉 周小雷[1] 陈路[1] 莫单丹[1] TANG Bing-lan;QIN Lang;JIANG Li;ZHOU Xiao-lei;CHEN Lu;MO Dan-dan(Key Laboratory of Medicinal Resources Protection and Genetic Improvement in Guangxi/Guangxi Engineering Research Center of TCM Resource Intelligent Creation,Guangxi Botanical Garden of Medicinal Plants,Nanning 530023,China;Guangxi Medical College,Nanning 530023,China)

机构地区：[1]广西壮族自治区药用植物园,广西药用资源保护与遗传改良重点实验室/广西壮族自治区中药资源智慧创制工程研究中心,广西南宁530023 [2]广西卫生职业技术学院,广西南宁530023

出　　处：《中成药》2023年第8期2585-2589,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(81660721);广西科技重大专项项目(桂科AA18242040);广西壮族自治区药品监督管理局药品安全科研项目(2022)。

摘　　要：目的研究小钻Kadsura longipedunculata Finet et Gagnep的化学成分。方法小钻80%乙醇提取物采用硅胶、ODS、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到7个化合物,分别鉴定为长南五味子素E(1)、schisphenlignan A(2)、5,8-环氧-6,7-二甲基-2′,3′,2″,3″-二亚甲基二氧基-4′,1″-二甲氧基-l,2∶3,4-二苯并-1,3-环辛二烯(3)、五味子酯甲(4)、南五味子内酯A(5)、五味子酸(6)、胡萝卜苷(7)。结论化合物1为新化合物,化合物2~3为首次从该植物中分离得到。AIM To study the chemical constituents from Kadsura longipedunculata Finet et Gagnep.METHODS The 80%ethanol extract from K.longipedunculata was isolated and purified by silica,ODS and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Seven compounds were isolated and identified as longipedunin E(1),schisphenlignan A(2),5,8-epoxy-6,7-dimethyl-2′,3′,2″,3″-dimethylenedioxy-4′,1″-dimethoxy-l,2∶3,4-dibenzo-1,3-cyclooctadiene(3),schisantherin A(4),kadsulactone A(5),schizandronic acid(6),daucosterol(7).CONCLUSION Compound 1 is a new compound.Compounds 2-3 are isolated from this plant for the first time.

关 键 词：小钻 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]