橙皮苷微囊剂的制备工艺方法及质量评价研究  

Study on Preparation and Quality Evaluation of Hesperidin Microcapsules

作　　者：梁健龙 杨鸿雁 陈新伟 何源源 蔡鸿飞 杜卓[1] 郭嘉亮[1,2] Liang Jianlong;Yang Hongyan;Chen Xinwei;He Yuanyuan;Cai Hongfei;Du Zhuo;Guo Jialiang(Foshan University,Foshan 528000;Jinan University,Guangzhou 510632;Guangzhou Hanfang Pharmaceutical Co.,Ltd.,510240,China)

机构地区：[1]佛山科学技术学院,广东佛山528000 [2]暨南大学,广东广州510632 [3]广州白云山汉方现代药业有限公司,广东广州510240

出　　处：《广东化工》2023年第14期28-30,70,共4页Guangdong Chemical Industry

基　　金：国家自然科学基金项目(81872832,82173781);广东省基础与应用基础研究基金自然科学基金项目(2019A1515010806);广东省教育厅重点领域专项(2020ZDZX2057);佛山科学技术学院口腔医学科研培育项目;广东省岭南中药全过程质量控制与精准分析工程技术研究中心支持项目。

摘　　要：目的:研究橙皮苷微囊的制备工艺并建立质量评价方法,筛选最优工艺处方。方法:以微囊形态、载药量和包封率为评价指标筛选制备橙皮苷微囊的工艺处方,建立紫外分光光度法对最佳制备工艺下制得的橙皮苷微囊进行含量测定与质量评价。结果:筛选出橙皮苷微囊的最佳制备条件是乳化时间为45 s,pH等电点为4.0,加水量为400 mL,加入固化剂甲醛的量为2.5 mL和氢氧化钠调节p H为8.5,微囊的载药量为21.30%,包封率为60.71%。结论:本研究最优工艺下制得橙皮苷微囊分层明显,微囊数量多,载药量和包封率好。通过建立紫外分光光度法测定橙皮苷含量的研究数据及结果为其制备方法和质量评价提供了理论参考。To explore the preparation technology of hesperidin microcapsules was studied,the quality evaluation method was established,and the optimal formulation was selected.Methods:The process prescription for the preparation of hesperidin microcapsules was screened by the shape,drug loading,and entrapment efficiency of microcapsules,and the content and quality of hesperidin microcapsules prepared under the optimum preparation process were determined and evaluated by ultraviolet spectrophotometry.Results:The best preparation conditions of hesperidin microcapsules were as follows:emulsification time 45 s,pH isoelectric point 4.0,water addition 400 mL,2.5 mL and sodium hydroxide adjusting pH 8.5,drug loading 21.30%,entrapment efficiency 60.71%.Conclusion:The hesperidin microcapsules were prepared with obvious delamination,large number of microcapsules,good drug loading and entrapment efficiency;the data and results of the study on the determination of hesperidin content by establishing UV spectrophotometry method provide theoretical reference for the preparation method and quality evaluation of other new dosage forms.

关 键 词：橙皮苷 微囊 制备工艺 质量评价 紫外分光光度法 

分 类 号：TQ[化学工程]