纳米材料在帕金森病治疗中的研究进展  

Recent Progress of Nanomaterials in The Treatment of Parkinson's Disease

作　　者：杨洁[1] 莫莎 张萌萌 何洁 张娜[1] 杨青青[1] Yang Jie;Mo Sha;Zhang Mengmeng;He Jie;Zhang Na;Yang Qingqing(Hanzhong Vocational and Technical College,Hanzhong Key Laboratory of Clinical Molecular Biology,Hanzhong 723002;Hanzhong Center for Food and Drug Control,Hanzhong 723000,China)

机构地区：[1]汉中职业技术学院,汉中临床分子生物学重点实验室,陕西汉中723002 [2]汉中市食品药品监督检验检测中心,陕西汉中723000

出　　处：《广东化工》2023年第14期93-96,90,共5页Guangdong Chemical Industry

基　　金：陕西省教育厅专项科研计划项目(自然科学类)(19JK0051)。

摘　　要：帕金森病(parkinson’sdisease,PD)被认为是一种好发于中老年人的神经退行性疾病,其发病机制尚未完全阐明。大量研究表明其致病机制与遗传、基因突变、神经炎症、线粒体功能障碍、神经黑色素过度累积、高水平的活性氧(reactive oxygen species,ROS)和α-突触核蛋白(alpha-synuclein,α-syn)的聚集密切相关。因纳米材料具有抗ROS、抑制α-syn聚集、保护药物、递送药物分子等方面的生理作用及优点,故人们不断发掘其在抗PD方面的潜在作用。本文综述了近年来最新研发的八类纳米材料在治疗PD方面的作用机制,介绍了纳米材料的化学结构、组成特点等,讨论了纳米材料修复和保护多巴胺能神经元的最新进展和新兴前沿。Parkinson's disease(PD)is considered to be a neurodegenerative disease that tends to occur in middle-aged and elderly people,but its pathogenesis has not been fully elucidated.Many studies have shown that its pathogenesis is closely associated with inheritance,gene mutation,neuroinflammation,mitochondrial dysfunction,excessive accumulation of neuromelanin,high levels of reactive oxygen species(ROS),and accumulation ofα-synuclein(α-syn).Due to their physiological effects and advantages of anti-ROS,preventingα-syn aggregation,preserving pharmaceuticals,and delivering therapeutic molecules,people are constantly exploring their potential role in anti-PD.This article reviews the mechanism ofeight types of newly developed nanomaterials in the treatment of PD,introduces the chemical structure and composition characteristics of nanomaterials,and discusses the latest progress and emerging frontiers of nanomaterials in the repair and protection of dopaminergic neurons.

关 键 词：纳米材料 帕金森病 活性氧 Α-突触核蛋白 

分 类 号：TQ[化学工程]