儿童及青少年骨成熟度对大脑皮质髓鞘发育的影响  

Impact of bone maturity on cerebral cortical myelination development in children and adolescents

作　　者：贾凤林 廖怡 宁刚[1] 张露 张毓瑾 张洪丁 孙怀强[3] 曲海波[1] JIA Fenglin;LIAO Yi;NING Gang;ZHANG Lu;ZHANG Yujin;ZHANG Hongding;SUN Huaiqiang;QU Haibo(Department of Radiology,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,Sichuan University,Chengdu 610041,China;Department of Operation Management and Evaluation,West China Second University Hospital,Sichuan University,Chengdu 610041,China;Magnetic Resonance Center,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西第二医院放射科、出生缺陷与相关妇儿疾病教育部重点实验室,四川成都610041 [2]四川大学华西第二医院运营管理与评价部,四川成都610041 [3]四川大学华西医院磁共振中心,四川成都610041

出　　处：《中国医学影像技术》2023年第8期1129-1132,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划项目(2018YFC1002202)。

摘　　要：目的观察骨成熟度对儿童及青少年大脑皮质髓鞘发育的影响。方法前瞻性纳入94名接受骨龄及脑部高分辨率MR检查的儿童及青少年,根据骨龄与实际年龄分为骨龄偏低组(n=20)、正常组(n=30)及偏高组(n=44);计算68个脑区T1W/T2W比值,以之表征脑皮质髓鞘含量;对性别、年龄等因素加以校正后,采用线性回归模型分析骨发育状态对各脑区皮质髓鞘发育的影响。结果3组间8个脑区皮质T1W/T2W比值差异有统计学意义(P均<0.05);骨龄偏高组左侧扣带回峡部、右侧眶额部皮质外侧及右侧缘上回皮质T1W/T2W比值低于,而左侧额中回上部、右侧枕外侧T1W/T2W比值高于骨龄正常组(P均<0.05);骨龄偏低组左侧中央后回、双侧内嗅区皮质T1W/T2W比值高于骨龄正常组(P均<0.05)。结论骨成熟度影响多个脑区皮质髓鞘发育,并具有区域异质性;骨龄偏高对皮质髓鞘发育的影响可能更为复杂。Objective To explore the impact of bone maturity on the development of cerebral cortical myelination in children and adolescents.Methods Totally 94 children and adolescents who underwent bone age assessment and high resolution MR examination of brain were prospectively enrolled and divided into low bone age group(n=20),normal bone age group(n=30)or high bone age group(n=44).The cortical myelin content of 68 brain regions were characterized by evaluating T1W/T2W ratio.After adjusting for influence factors such as gender and age,a linear regression model was used to analyze the impact of bone development status on cortical myelin sheath development in various brain regions.Results After adjusting for gender and age,significant differences of T1W/T2W ratio were found in 8 brain regions among 3 groups(all P<0.05).In high bone age group,T1W/T2W ratio of the left isthmus cingulate,right lateral orbitofrontal and right supramarginal cortex were lower,while of the left caudal middle frontal and right lateral occipital cortex were higher than those in normal bone age group(all P<0.05).T1W/T2W ratio of the left central posterior and bilateral entorhinal cortex in low bone age group was higher than those in normal bone age group(all P<0.05).Conclusion Bone maturity could impact the development of cortical myelination in multiple brain regions and exhibit regional heterogeneity,and the influence of high bone age on cortical myelination development might be more complex.

关 键 词：大脑皮质 年龄测定 骨骼 磁共振成像 前瞻性研究 

分 类 号：R339.35[医药卫生—人体生理学] R445.1[医药卫生—基础医学]