甘肃省120例成人寻常型银屑病住院患者甲损害现况  

A cross-sectional study of nail involvement of 120 on adult inpatients of psoriasis vulgaris in Gansu Province

作　　者：黄蓉 张静[1] 骆志成[1] 吴瑾 Huang Rong;Zhang Jing;Luo Zhicheng;Wu Jin(Department of Dermatology,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院皮肤科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2023年第6期62-67,共6页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(22JR5RA1003)。

摘　　要：目的探讨甘肃省成人寻常型银屑病住院患者甲损害发生率、临床特征、甲损害组与无甲损害组在人口学、疾病特征、生活质量评分及实验室检查之间的差异。方法收集兰州大学第二医院2021年12月-2023年1月住院的120例成人寻常型银屑病住院患者的相关资料,将患者分为甲损害组与无甲损害组,分析甲银屑病相关临床特征。结果纳入患者中67.5%合并甲损害,其中点状凹陷最常见,其次为甲剥离和甲下角化过度,甲半月红斑最少,25.9%伴甲皱襞受累。甲损害组与无甲损害组在性别、年龄、职业、病程、有无舌损害、病情严重程度方面差异有统计学意义(P<0.05)。甲银屑病严重程度指数与甲损害病程、甲银屑病生活质量量表评分相关;皮肤病生活质量指数与年龄、病情严重程度相关。2组患者实验室检查指标无明显差异。甲银屑病生活质量量表评分前4位为情绪、工作、家务劳动和甲疼痛。结论甘肃省成人寻常型银屑病住院患者伴甲损害常见,发生较多的为点状凹陷、甲剥离和甲下角化过度。男性、年龄大、体力劳动者、病程长、伴舌损害、病情严重者更易出现甲损害。甲损害主要影响患者的情绪、工作和家务劳动。Objective To discuss the prevalence and clinical features of nail psoriasis in adult inpatients with psoriasis vulgaris in Gansu Province,and the differences in demographic characteristics,disease characteristics,quality of life scores and laboratory tests between patients with nail involvement and those without.Methods Clinical data were collected from 120 adult inpatients of psoriasis vulgaris between December,2021 to January,2023,and the patients were divided into a nail psoriasis group and one without nail psoriasis.The clinical characteristics were analyzed.Results Of the patients with psoriasis vulgaris,67.5%had nail psoriasis.The most common clinical manifestations of nail psoriasis were pitting,followed by onycholysis,subungual hyperkeratosis,with red spots in lunula being the least.25.9%were affected by combined nail fold.There were statistical differences in terms of gender,age,occupation,duration of psoriasis,tongue damage,and psoriasis area and severity index(PASI)score between the two groups(P<0.05).The total nail psoriasis severity index score was correlated with the duration of nail psoriasis and nail psoriasis quality of life scale(NPQ10)score.Age and PASI score were correlated with nail psoriasis quality of life scale score.There were no significant differences between the two groups in the common laboratory test indices.The top four NPQ10 scores were mood,work,household chores and nail pain.Conclusion Nail psoriasis was common in adult inpatients with psoriasis vulgaris in Gansu Province.The most types found were pitting,onycholysis and subungual hyperkeratosis.Men,older people,manual workers and those with a longer course of disease,tongue damage and high PASI scores were more likely to develop nail psoriasis.Nail psoriasis mainly affects the patient's mood,work and household tasks.

关 键 词：寻常型银屑病 甲银屑病 临床特征 生活质量 

分 类 号：R758.72[医药卫生—皮肤病学与性病学]