触珠蛋白基因多态性与冠心病易感性的Meta分析  

A Meta-analysis on haptoglobin polymorphism and susceptibility of coronary heart disease

作　　者：孟帆 陈芳雨 徐盼 张超[1] 左红霞[1] 汪龙 Meng Fan;Chen Fangyu;Xu Pan;Zhang Chao;Zuo Hongxia;Wang Long(Center for Evidence-Based Medicine,Taihe Hospital of Shiyan City,Shiyan 442000,China;不详)

机构地区：[1]十堰市太和医院循证医学中心,十堰442000

出　　处：《中国循证心血管医学杂志》2023年第5期529-536,共8页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的 系统评价触珠蛋白(Hp)基因多态性与冠状动脉粥样硬化性心脏病(冠心病)发病风险的关系。方法 系统检索9个电子数据库,包括PubMed、EMbase、Cochrane Library、Web of Science、CINAHL、CBM、CNKI、VIP和WanFang数据库,搜集从建库到2022年1月18日有关Hp基因多态性和冠心病发病风险关系的研究。由2名研究者独立筛选文献,提取资料并评价纳入研究的偏倚风险后,使用STATA 15.1进行统计学分析。使用合并优势比(OR)和95%置信区间(CI)在5种遗传模型中评价Hp基因多态性和冠心病风险之间的关联。此外,应用试验序贯分析(TSA)和假阳性报告概率分析(FPRP)验证结果的可靠性。结果 共纳入17篇文献(含18项研究),包括4283例冠心病患者和29 409例对照者。Meta分析结果显示:在总体人群的除隐性模型的其他四种基因模型中,触珠蛋白基因多态性与患冠心病之间存在显著相关性(在显性模型中,Hp1-1+Hp2-1 vs.Hp2-2:OR=0.74,95%CI=0.61~0.90,P=0.003,I^(2)=74.7%)。在以种族为亚组的亚组分析中,在亚洲人群中,Hp基因多态性与冠心病发病风险有显著的关联(Hp1-1+Hp2-1 vs.Hp2-2:OR=0.68,95%CI:0.51~0.90,P=0.007),而在其他人群亚组中未发现存在显著关联(P>0.05)。累积分析和敏感性分析结果均显示显性模型的结果稳定。显性基因模型的TSA分析结果说明本文章得出的结果稳定可靠。此外,FPRP分析结果也表明研究结果的假阳性报告的可能性很小。结论 Hp基因多态性与冠心病的发病风险存在关联,Hp1等位基因携带者总体上患冠心病风险较小,Hp1等位基因可能是亚洲人群冠心病的潜在保护因素。Objective To review systematically the relationship between the polymorphism of haptoglobin(Hp)and risk of coronary heart disease(CHD).Methods The databases of PubMed,EMbase,Cochrane Library,Web of Science,CINAHL,CBM,CNKI,VIP and WanFang Data were systematically retrieved for collecting the studies on relationship between Hp polymorphism and CHD risk from database establishment time to Jan.18,2022.The literature was screened,data was extracted and risk of bias was reviewed in included studies by 2 investigators independently,and then STATA 15.1 software was used for statistical analysis.The association between Hp polymorphism and CHD risk was evaluated in 5 genetic models by using combined odds ratios(OR)and 95%confidence intervals(CI).In addition,trial sequential analysis(TSA)and false positive reporting probability analysis(FPRP)were applied to verify the reliability of the results.Results A total of 17 publications(including 18 studies)were included involving 4283 patients with CHD and 29409 controls.The results of Meta-analysis showed that there was a significant corelation between Hp polymorphism and CHD in 4 genetic models except of recessive model in the overall population(in dominant model,Hp1-1+Hp2-1 vs.Hp2-2:0R=0.74,95%CI:0.61~0.90,P=0.003,P=74.7%).The results of subgroup analysis based on race,there was a significant association between Hp polymorphism and risk of CHD in the Asian population,(eg,in dominant model,Hp1-1+Hp2-1 us.Hp2-2:0R=0.68,95%CI:0.51~0.90,P=0.007),while no significant association was found in other population subgroups(P>0.05).The results of both cumulative and sensitivity analyses showed stable results for dominant model.The results of TSA analysis of dominant gene model indicated stable and reliable results.In addition,the results of FPRP analysis also indicated that the possibility of false positive reporting of the study results was minimal.Conclusion Hp polymorphism is associated with the risk of developing CHD,Hpl allele carriers have a lower risk of developing CHD overall,and

关 键 词：冠心病 触珠蛋白 基因多态性 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]