血清ST2、PLA2、血小板活化物对急性心肌梗死患者PCI术后MACE事件的预测价值  

Analysis of Prognostic value of serum ST2,PLA2 and platelet activators for MACE events in patients with acute myocardial infarction after PCI

作　　者：崔蕊[1] 赵云凤 于琪力 宋婷婷[1] 刘丽[1] Cui Rui;Zhao Yunfeng;Yu Qili;Song Tingting;Liu Li(Department of Cardiovascular Medicine,The First Hospital of Qinhuangdao,Qinhuangdao,Hebei,066000,China;不详)

机构地区：[1]秦皇岛市第一医院心血管内科,秦皇岛066000

出　　处：《中国循证心血管医学杂志》2023年第5期605-608,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的 探讨血清可溶性生长刺激表达基因2蛋白(ST2)、磷脂酶A2 (PLA2)、血小板活化物对急性心肌梗死患者经皮冠状动脉介入(PCI)术后心血管不良事件(MACE)事件的预测价值。方法 选择2020年1月至2021年12月我院接诊的155例急性心肌梗死患者,PCI术后随访6月,术后发生MACE的45例设为MACE组,110例术后未发生MACE的设为对照组,分析两组一般临床资料、血清ST2、PLA2、血小板活化物水平变化情况,分析急性心肌梗死患者PCI术后MACE事件的危险因素,采用ROC曲线分析血清ST2、PLA2、血小板活化物对PCI术后MACE事件的预测价值。结果两组年龄、性别、体质指数、糖尿病史比较差异无统计学意义(P>0.05),MACE组舒张压、收缩压低于对照组,心率及心衰病史高于对照组,比较差异显著(P<0.05);MACE组患者血清ST2、PLA2、PAC-1、CD40L及CD62p水平显著高于对照组,比较差异具有统计学意义(P<0.05);多因素非条件Logistic分析显示,血清ST2、PLA2、PAC-1、CD40L及CD62p均是PCI术后MACE事件发生的独立危险因素。对血清ST2、PLA2、PAC-1、CD40L及CD62p预测PCI术后MACE事件进行ROC曲线分析,结果显示,血清ST2、PLA2、PAC-1、CD40L及血清CD62p预测PCI术后MACE事件发生的截断值分别为20.69 ng/ml、273.87 ng/ml、9.01%、1.90%及6.63%,(P<0.05)。结论 血清ST2、PLA2、血小板活化物均是急性心肌梗死患者PCI术后MACE事件的危险因素,在心血管不良事件的发生中有一定的预测价值。Objective To study Analysis of the Prognostic value of serum Soluble growth stimulator expression gene two protein(ST2),Phospholipase A2(PLA2),and platelet activators for Cardiovascular Adverse Events(MACE)events in patients with acute myocardial infarction after Percutaneous coronary intervention(PCI).Methods One hundred fty-five patients with acute myocardial infarction received in our hospital from January 2020 to December 2021 were selected and followed up for six months after surgery.Forty-five patients with postoperative MACE were set into the MACE group,and 110 patients without postoperative MACE were set into the control group.The two groups'general clinical data,serum ST2,PLA2,and platelet activator levels,were analyzed.The risk factors of MACE events in patients with acute myocardial infarction after PCI were analyzed,and the predictive value of serum ST2,PLA2,and platelet activators for MACE events after PCI was analyzed by ROC curve.Results There was no significant difference in age,sex,body mass index,and history of diabetes between the two groups(P>0.05).The diastolic and systolic blood pressure in the MACE group were lower than those in the control group,and the heart rate and history of heart failure in the MACE group were higher than those in the control group,with significant differences(P<0.05).Serum levels of ST2,PLA2,PAC-1,CD40L,and CD62p in the MACE group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Multivariate Logistic analysis showed that serum ST2,PLA2,PAC-1,CD40L,and CD62p were independent risk factors for MACE events after PCI.ROC curve analysis of serum ST2,PLA2,PAC-1,CD40L,and CD62p to predict MACE events affer PCI showed that The cutoff values of serum ST2,PLA2,PAC-1,CD40L,and CD62p in predicting MACE events after PCI was 20.69 ng/ml,respectively,273.87 ng/ml,9.01%,1.90%,and 6.63%(P<0.05).Conclusion Serum ST2,PLA2,and platelet activators are all risk factors for MACE events after PCI in patients with acute myocard

关 键 词：可溶性生长刺激表达基因2蛋白 磷脂酶A2 血小板活化物 急性心肌梗死 心血管不良事件 

分 类 号：R542.22[医药卫生—心血管疾病]