急性心肌梗死患者NLR、LMR、PLR的表达及与PCI术后冠状动脉无复流的关系  

The expression of NLR,LMR and PLR in patients with acute myocardial infarction and their relationship with no coronary reflow after PCI

作　　者：刘闯[1] 闫佩佩[1] 陈雅丽[1] 李向辉[1] Liu Chuang;Yan Peipei;Chen Yali;Li Xianghui(Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,450000,China;不详)

机构地区：[1]郑州大学第一附属医院心内科,郑州450000

出　　处：《中国循证心血管医学杂志》2023年第5期616-618,626,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨并分析急性心肌梗死(AMI)患者中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)、血小板/淋巴细胞比率(PLR)的表达及与经皮冠状动脉介入治疗(PCI)术后冠状动脉(冠脉)无复流的关系。方法回顾性分析郑州大学第一附属医院心内科自2019年4月至2022年4月接诊的420例AMI行PCI的患者作为研究对象,根据术后无复流的发生情况进行分组,其中术后发生无复流的52例患者为无复流组,未发生无复流的368例患者为再灌注组。比较两组患者的体质指数(BMI)、吸烟、饮酒、高血压、糖尿病、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、支架情况(数量、直径、长度)、以及NLR、LMR、PLR的水平表达,并采用多因素Logistic回归分析影响冠心病患者PCI术后发生ISR的危险因素。结果两组患者的BMI、TC、TG比较,差异无统计学意义(P>0.05),无复流组吸烟、饮酒、高血压、糖尿病、支架数量<2枚、支架直径<3.5mm、支架长度<30mm的患者明显多于再灌注组,LDL-C水平明显高于再灌注组;无复流组患者的NLR、LMR、PLR水平均明显高于再灌注组(P<0.05);经Logistic回归分析显示,NLR、LMR、PLR均是影响AMI患者PCI术后冠脉无复流的危险因素(P<0.05)。结论AMI患者PCI术后冠脉无复流与NLR、LMR、PLR密切相关,临床上对于此类高危因素患者应予以重视,并给予相应防治措施。Objective To investigate and analyze the expression of neutrophil/lymphocyte ratio(NLR),lymphocyte/monocyte ratio(LMR),and platelet/lymphocyte ratio(PLR)in patients with acute myocardial infarction(AMI)and their relationship with the absence of coronary artery reflow after percutaneous coronary intervention(PCI).Methods A retrospective analysis of 420 patients with AMI treated by PCI in the Department of Cardiology,the First Affiliated Hospital of Zhengzhou University from April 2019 to April 2022 was conducted as the research object;the patients were grouped according to the occurrence of no-reflow affer surgery,among which 52 patients with no-reflow after surgery were classified as a no-reflow group and 368 patients with no reperfusion group.The levels of body mass index(BMI),smoking,drinking,hypertension,diabetes,triacylglycerol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),number of stents,stent diameter and length,NLR,LMR,and PLR were compared between the two groups;multivariate Logistic regression was used to analyze the risk factors of ISR in patients with coronary heart disease after PCI.Results There was no statistically significant difference in BMI,TC,and TG between the two groups(P>0.05);in the no-reperfusion group,patients with smoking,drinking,hypertension,diabetes,the number of stents<2 pieces,the diameter of stents<3.5 mm,and the length of stents<30 mm were significantly more than those in the reperfusion group,and the level of LDL-C was significantly higher than that in the reperfusion group.The levels of NLR,LMR,and PLR in the no-reperfusion group were significantly higher than those in the reperfusion group(P<0.05).Logistic regression analysis showed that NLR,LMR,and PLR were all risk factors for AMI patients without coronary reflow after PCI(P<0.05).Conclusion The absence of coronary reflow after PCI in AMI patients is closely related to NLR,LMR,and PLR;clinical attention should be paid to these high-risk factors,and corresponding prevention and treatment measures should be g

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 中性粒细胞/淋巴细胞比值 淋巴细胞与单核细胞比值 血小板/淋巴细胞比率 

分 类 号：R542.22[医药卫生—心血管疾病]