Developmental genes during placentation:insights from mouse mutants  

作　　者：Jinhua LU Qiang WANG Bingyan WANG Fengchao WANG Haibin WANG 

机构地区：[1]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]Graduate University of the Chinese Academy of Sciences,Beijing 100039,China

出　　处：《Frontiers in Biology》2011年第4期300-311,共12页生物学前沿（英文版）

基　　金：the National Basic Research Program of China(No.2011CB944401);the National Natural Science Foundation of China(Grant Nos.2299390,31000659);the Beijing Natural Science Foundation(No.5091002);Haibin Wang is a recipient of“National Science Foundation for Distinguished Young Scholars”(No.30825015).

摘　　要：Placenta,a temporary organ first formed during the development of a new life is essential for the survival and growth of the fetus in eutherian mammals.It serves as an interface for the exchange of nutrients,gases and wastes between the maternal and fetal compartments.During the past decades,studies employing gene-engineered mouse mutants have revealed a wide range of signaling molecules governing the trophoblast development and function during placentation under various pathophysiological conditions.Here,we summarize the recent progress with particular respect to the involvement of developmental genes during placentation.

关 键 词：developmental gene PLACENTATION mouse mutant 

分 类 号：R71[医药卫生—妇产科学]