基于甘草酸自缔合制备6-姜辣素脂质体及其评价  

Preparation and Evaluation of 6-gingerol Liposomes based on Glycyrrhizic Acid Self-association

作　　者：顾晨露 金绍娣[1] 顾东雅[1] 葛竹妹 Gu Chenlu;Jin Shaodi;Gu Dongya;Ge Zhumei(Department of Medicine and Health,Yancheng Industrial Vocational and Technical College,Yancheng 224000;Suqian Traditional Chinese Medicine Hospital,Suqian 223800,China)

机构地区：[1]盐城工业职业技术学院药品与健康学院,江苏盐城224000 [2]宿迁市中医院,江苏宿迁223800

出　　处：《广东化工》2023年第15期36-38,46,共4页Guangdong Chemical Industry

摘　　要：目的:基于甘草酸能够自发缔合的特点,以甘草酸为载体制备6-姜辣素脂质体,并对其进行制剂学表征。方法:表面张力法测定甘草酸临界胶束浓度,采用薄膜分散法制备6-姜辣素脂质体,正交试验设计最优处方,利用差式扫描热分析仪、透射电镜及粒径电位仪进行表征。结果:最优处方为单硬脂酸甘油酯3%、辛葵酸甘油酯3%、甘草酸14%、药脂比1∶10(w/w),根据该处方成功制备出类球形的6-姜辣素脂质体,测得包封率为94.65±1.05%,载药量为6.01±0.41%。结论:基于正交试验设计的甘草酸修饰的6-姜辣素脂质体制备成功,稳定、均一且包封率、载药量良好。Objective:Based on the characteristics of spontaneous association of glycyrrhizic acid,the 6-gingerol liposomes were prepared with glycyrrhizic as carrier and were analyzed and characterized by morphology.Methods:The critical micelle concentration of glycyrrhizic acid was determined by a surface tensiometer.6-gingerol liposomes were prepared by thin film dispersion method,and the optimal formulation was designed based on orthogonal experiment.The particle size and potential values were measured by differential scanning thermal analysis,transmission electron microscopy and particle size potentiometer.Results:Taking the particle size as the index and considering the four factors,the optimal formulation designed by orthogonal experiment was glycerin monstearate 3%,glyceryl octanoate 3%,glycyrrhizic 14%,drug/lipid 1∶10(w/w).According to the formula,spherical 6-gingerol liposomes were successfully prepared,with an encapsulation efficiency of 94.65±1.05% and a drug loading of 6.01±0.41%.Conclusion:The glycyrrhizic modified 6-gingerol liposome designed based on the orthogonal test was successfully prepared,which was stable,uniform,and had good encapsulation efficiency and drug loading.

关 键 词：6-姜辣素 甘草酸 脂质体 差式扫描热分析 正交试验设计 

分 类 号：R94[医药卫生—药剂学]