3-甲基-6-氯尿嘧啶的合成  

Synthesis of 3-methyl-6-chlorouracil

作　　者：王子才 许成亮 王亚琦 Wang Zicai;Xu Chengliang;Wang Yaqi(Linyi Hengtai Safety Technology Co.,Ltd.,Shandong,276034;Shandong Linyi Sanfeng Chemical Co.,Ltd.,Shandong,276034;School of Chemistry&Chemical Engineering,Linyi University,Shandong,276005)

机构地区：[1]临沂市恒泰安全科技有限公司,山东276034 [2]山东省临沂市三丰化工有限公司,山东276034 [3]临沂大学化学化工学院,山东276005

出　　处：《当代化工研究》2023年第17期167-169,共3页Modern Chemical Research

摘　　要：3-甲基-6-氯尿嘧啶是一种合成阿格列汀、毒黄素和黄素盐的中间体,其合成对于药物的研究和有机合成具有重要意义。论文以乙酸酐为脱水剂,通过丙二酸与甲基脲在乙酸溶剂中发生脱水缩合合成中间产物1-甲基嘧啶-2,4,6(1H,3H,5H)-三酮。再用三氯氧磷与中间体在少量水的催化下发生氯化合成目标化合物。讨论了反应物之间不同的配比、反应温度、反应时间等反应条件,对3-甲基-6-氯尿嘧啶合成产率的影响。6-chloro-3-methyluracil is an intermediate for the synthesis of alogliptin,toxoflavin and flavinium salts,its synthesis is of great sig-nificance for drug research and organic synthesis.Using methylurea,malonic acid as starting material,the paper synthesizes the intermediate 1-meth-ylpyrimidin-2,4,6(1H,3H,5H)-trione with the dehydration effect of acetic anhydride in acetic acid.The target compound is synthesized by chlorina-tion of the intermediate with phosphorus oxychloride under the catalysis of a small amount of water.The effects of reaction conditions such as different ratios of reactants,reaction temperature,and reaction time on the yield of 3-methyl-6-chlorouracil synthesis were discussed.

关 键 词：丙二酸 甲基脲 三氯氧磷 3-甲基-6-氯尿嘧啶 

分 类 号：O626.3[理学—有机化学]