PAgT及血清FIB、D-D、P、β-HCG水平联合检测预测孕早期自然流产的价值  

Predictive analysis of combined detection of PAgT,serum FIB,D-D,P,β-HCG levels in early pregnancy spontaneous abortion

作　　者：罗密娥 毛小兰 LUO Mi′e;MAO Xiaolan(Department of Obstetrics and Gynecology,Maternal and Child Health Hospital of Shanggao County,Yichun,Jiangxi 336400,China;Department of Obstetrics and Gynecology,Maternal and Child Health Hospital of Wanzai County,Yichun,Jiangxi 336100,China)

机构地区：[1]江西省宜春市上高县妇幼保健院妇产科,江西宜春336400 [2]江西省宜春市万载县妇幼保健院妇产科,江西宜春336100

出　　处：《检验医学与临床》2023年第16期2408-2411,2415,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血小板聚集率(PAgT)及血清纤维蛋白原(FIB)、D-二聚体(D-D)、孕酮、β-人绒毛膜促性腺激素(β-HCG)水平联合检测对孕早期自然流产的预测价值。方法选取该院2019年4月至2020年10月接收的有自然流产危险因素的孕妇142例纳入观察组,另选取同期健康孕妇135例纳入对照组。所有研究对象均检测PAgT及血清FIB、D-D、孕酮、β-HCG水平。比较两组上述指标和孕早期自然流产发生率;将观察组孕早期自然流产者纳入发生组,否则纳入未发生组,比较两亚组上述指标水平;绘制受试者工作特征(ROC)曲线,采用曲线下面积(AUC)评价PAgT、血清FIB、D-D、孕酮、β-HCG水平单独与联合检测对有自然流产危险因素的孕妇发生孕早期自然流产的预测效能。结果观察组PAgT、血清FIB和D-D水平均高于对照组,血清孕酮和β-HCG水平均低于对照组,差异有统计学意义(P<0.05)。观察组孕早期自然流产发生率为32.39%(46/142),高于对照组的2.22%(3/135),差异有统计学意义(P<0.05)。发生组PAgT、血清FIB和D-D水平均高于未发生组,血清孕酮和β-HCG水平均低于未发生组,差异有统计学意义(P<0.05)。PAgT及血清FIB、D-D、孕酮、β-HCG水平联合检测预测孕早期自然流产的灵敏度和AUC分别为97.83%和0.988,均高于各项指标单独检测(P<0.05),特异度与各项指标单独检测比较,差异均无统计学意义(P>0.05)。结论相较于健康孕妇,有孕早期自然流产风险的孕妇PAgT、血清FIB和D-D水平偏高,而血清孕酮和β-HCG水平偏低,上述指标联合检测可提高对有自然流产危险因素的孕妇孕早期自然流产的预测效能。Objective To investigate the predictive value of platelet aggregation rate(PAgT),serum fibrinogen(FIB),D-dimer(D-D),progesterone andβ-human chorionic gonadotropin(β-HCG)levels in spontaneous abortion in early pregnancy.Methods A total of 142 pregnant women with risk factors for spontaneous abortion admitted to Maternal and Child Health Hospital of shanggao county from April 2019 to October 2020 were included in the observation group,and 135 women with normal pregnancy during the same period were included in the control group.The levels of PAgT,serum FIB,D-D,progesterone andβ-HCG were detected.The above indexes and the incidence of spontaneous abortion in early pregnancy were compared between the two groups.Spontaneous abortion in the early pregnancy of the observation group was included in the occurrence group,otherwise included in the non-occurrence group,and the above indexes were compared between the two subgroups.Receiver operating characteristic(ROC)curve was plotted,and area under the curve(AUC)was used to evaluate the predictive efficacy of PAgT,serum FIB,D-D,progesterone andβ-HCG levels alone and in combination for spontaneous abortion in pregnant women with risk factors for spontaneous abortion in early pregnancy.Results The levels of PAgT,serum FIB and D-D in observation group were higher than those in control group,the levels of serum progesterone andβ-HCG were lower than those in control group,with statistical significance(P<0.05).The incidence rate of spontaneous abortion in early pregnancy in the observation group was 32.39%(46/142),which was higher than that in the control group[2.22%(3/135)],and the difference was statistically significant(P<0.05).The levels of PAgT,serum FIB and D-D in the occurrence group were higher than those in the non-occurrence group,and the levels of serum progesterone andβ-HCG were lower than those in the non-occurrence group,with statistical significance(P<0.05).The sensitivity and AUC of combined detection of PAgT,serum FIB,D-D,progesterone andβ-HCG to predict sp

关 键 词：血小板聚集率 纤维蛋白原 D-二聚体 孕酮 Β-人绒毛膜促性腺激素 孕早期 自然流产 

分 类 号：R446.1[医药卫生—诊断学]