长链非编码RNA和微小RNA在子痫前期发病机制中的研究进展  

Research progress of long non-coding RNA and miRNA in pathogenesis of preeclampsia

作　　者：李颖[1] 王健[1] 顾秀峰[1] 李玉明 胡金朋 Ying LI;Jian WANG;Xiu-Feng GU;Yu-Ming LI;Jin-Peng HU(Department of Cardiology,Tianjin Fourth Central Hospital,Tianjin 300140,China;Research Department of Characteristic Medical Center of PAP,Tianjin 300162,China)

机构地区：[1]天津市第四中心医院心内科,天津300140 [2]武警特色医学中心研究部,天津300162

出　　处：《医学新知》2023年第4期280-284,共5页New Medicine

基　　金：国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项(2017YFC1307602);武警后勤部科研项目(CWJ18L004)。

摘　　要：子痫前期(preeclampsia,PE)是一种以妊娠期高血压和蛋白尿为特征的血管性疾病,是孕产妇及胎儿死亡的主要病因之一。胎盘在PE的发病中起着核心作用,但其发生机制尚未阐明。非编码RNA功能众多,已有研究表明长链非编码RNA(long non-coding,lncRNA)和微小RNA(microRNA,miRNA)可通过影响胎盘滋养层细胞功能对PE的发生与发展产生影响。为此,本研究就lncRNA和miRNA在PE发病机制中的研究进展进行综述,为PE的预防与治疗提供参考。Preeclampsia(PE)is a vascular disease characterized by hypertension and proteinuria during pregnancy and is one of the leading causes of maternal and fetal mortality.The placenta plays a central role in the pathogenesis of PE,but the mechanism of its occurrence has not been elucidated.Non-coding RNAs have numerous functions,and it has been shown that long non-coding RNA(lncRNA)and microRNA(miRNA)can influence the development and progression of PE by affecting placental trophoblast cell function.To this end,this study reviews the research progress of lncRNA and miRNA in the pathogenesis of PE,and provides a reference for the prevention and treatment of PE.

关 键 词：子痫前期 长链非编码RNA 微小RNA 

分 类 号：R714.244[医药卫生—妇产科学]