入院早期血小板水平与多器官功能障碍综合征相关性的分析  

Analysis of the correlation between platelet level and multiple organ dys function syndrome in early admission

作　　者：吴建华 郭鹏辉 WU Jianhua;GUO Penghui(Nephrology,Huizhou Zhongda Huiya Hospital,Huizh ou Guangdong 516081;Gastroenterology,Huizhou Zhongda Huiya Hospital,Huizh ou Guangdong 516081)

机构地区：[1]惠州市中大惠亚医院肾内科,广东惠州516081 [2]惠州市中大惠亚医院消化内科,广东惠州516081

出　　处：《当代医药论丛》2023年第16期24-26,共3页

基　　金：惠州市科技专项项目(2017Y231);项目名称:血管性血友病因子裂解蛋白酶活性在伴血栓性微血管病的多器官功能障碍中的意义。

摘　　要：目的:分析入院早期血小板(PLT)水平与多器官功能障碍综合征(MODS)的相关性。方法:收集2018年1月至2021年12月期间入住惠州市中大惠亚医院重症医学科(ICU)的MODS患者共78例,根据PLT水平分成三组:PLT<50×10^(9)/L组,PLT(50~99)×10^(9)/L组,PLT≥100×10^(9)/L组。入院时立即采血检验,并记录各组性别、年龄、PLT、血降钙素原(PCT)、血乳酸(Lac)、器官功能障碍数目以及疾病转归等情况,分析三组中各指标的特点以及MODS的危险因素。结果:(1)在78例MODS患者中,入院早期PLT减少的患者有40例,占比51.28%。(2)三组不同PLT水平患者的PCT、Lac及疾病转归情况相比,差异有统计学意义(P<0.05)。PLT<50×10^(9)/L组的PCT较其他两组明显升高,PLT<50×10^(9)/L组及PLT(50~99)×10^(9)/L组的Lac较PLT≥100×10^(9)/L组明显升高。(3)PLT越低,MODS患者的死亡率越高。(4)多元线性回归分析显示,PLT、Lac、PCT与MODS具有相关性(P<0.05)。结论:入院早期的PLT减少及Lac、PCT升高是MODS的危险因素,对疾病严重程度及转归的预测具有一定作用。Objective:To analyze the correlation between platelet(PLT)levels and multiple organ dysfunction syndrome(MODS)in the early stage of admission.Methods:A total of 78 MODS patients admitted to the Intensive Care Unit(ICU)of Zhongda Huiya Hospital in Huizhou City from January 2018 to December 2021 were collected and divided into three groups according to PLT level:PLT<50×10^(9)/L group,PLT(50~99)×10^(9)/L group,and PLT≥100×10^(9)/L group.Blood tests were taken immediately upon admission,and gender,age,PLT,blood procalcitonin(PCT),blood lactic acid(Lac),number of organ dysfunction and disease outcomes of each group were recorded.The characteristics of each index in the three groups and the risk factors of MODS were analyzed.Results:(1)Among 78 patients with MODS,PLT decreased in 40 patients(51.28%)at early admission.(2)There were statistically significant differences in PCT,Lac and disease outcomes among the three groups with different PLT levels(P<0.05).The PCT of PLT<50×10^(9)/L group was significantly higher than that of the other two groups,and the Lac of PLT<50×10^(9)/L group and PLT(50~99)×10^(9)/L group was significantly higher than that of PLT≥100×10^(9)/L group.(3)The lower the PLT,the higher the mortality of MO DS patients.(4)Multiple linear regression analysis showed that PLT,Lac and PCT were correlated with MODS(P<0.05).Conclusion:The decrease of PLT and the increase of Lac and PCT in the early stage of admission are the risk factors of MODS,which have a certain role in predicting the severity and outcome of the disease.

关 键 词：血小板 多器官功能障碍综合征 危险因素 血降钙素原 血乳酸 

分 类 号：R446[医药卫生—诊断学]