益生菌配合常规药物治疗对妊娠期糖尿病患者血糖、血脂以及妊娠结局的影响  

Effects of probiotic combined with conventional drug treatment on blood glucose,blood fat and pregnancy outcome in patients with gestational diabetes mellitus

作　　者：石倬宇 常庆芬 SHI Zhuoyu;CHANG Qingfen(Xi'an Huyi District Maternal and Child Health Care and Family Planning Service Center,Xi'an 710300;Xi'an Fourth Hospital,Xi'an 710004,China)

机构地区：[1]西安市鄠邑区妇幼保健计划生育服务中心,陕西西安710300 [2]西安市第四医院,陕西西安710004

出　　处：《临床医学研究与实践》2023年第24期86-89,共4页Clinical Research and Practice

摘　　要：目的 探讨益生菌配合常规药物治疗对妊娠期糖尿病(GDM)患者血糖、血脂以及妊娠结局的影响。方法选取2020年2月至2021年1月收治的80例GDM患者为研究对象,依据入院编号的奇偶性将其分为对照组与观察组,每组40例。对照组实施常规药物治疗,观察组在对照组基础上予以益生菌治疗。比较两组的治疗效果。结果 给药2周后,观察组的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均显著低于对照组,高密度脂蛋白胆固醇(HDL-C)水平及白细胞分化抗原4阳性(CD4^(+))、自然杀伤(NK)细胞显著高于对照组(P<0.05)。观察组的血糖达标率显著高于对照组,不良妊娠结局总发生率显著低于对照组(P<0.05)。结论 益生菌配合常规药物治疗GDM可显著提升患者的血糖控制效果,改善妊娠结局。Objective To explore the effects of probiotic combined with conventional drug treatment on blood glucose,blood fat and pregnancy outcome in patients with gestational diabetes mellitus(GDM).Methods Eighty patients with GDM admitted from February 2020 to January 2021 were selected as the study objects and divided into control group and observation group according to the parity of admission numbers,with 40 cases in each group.The control group received conventional drug treatment,and the observation group received probiotic treatment on the basis of the control group.The therapeutic effects of the two groups were compared.Results After 2 weeks of administration,the levels of fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PG),glycated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the observation group were significantly lower than those in the control group,the level of high density lipoprotein cholesterol(HDL-C)and cluster of differentiation 4 positive(CD4^(+))and natural killer(NK)cell were significantly higher than those in the control group(P<0.05).The standard-reaching rate of blood glucose of the observation group was significantly higher than that of the control group,the total incidence of adverse pregnancy outcomes was significantly lower than that in the control group(P<0.05).Conclusion The probiotic combined with conventional drug in the treatment of GDM can significantly improve the blood glucose control effect of patients,and improve pregnancy outcome.

关 键 词：益生菌 妊娠期糖尿病 血糖 血脂 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]