冠状动脉内溶栓联合PCI治疗对急性心肌梗死患者的影响  

Effect of Intracoronary Thrombolysis Combined with PCI on Patients with Acute Myocardial Infarction

作　　者：陈磊杰 宋鹤 CHEN Lei-jie;SONG He(Hebi People's Hospital,Henan Hebi 458030)

机构地区：[1]鹤壁市人民医院,河南鹤壁458030

出　　处：《深圳中西医结合杂志》2023年第11期69-72,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察冠状动脉内溶栓联合经皮冠状动脉介入(PCI)治疗对急性心肌梗死(AMI)患者血清小分子核糖核酸(miRNA)序列与临床指标的影响。方法:选取2020年1月至2023年1月鹤壁市人民医院收治的74例AMI患者资料,根据治疗方案不同分为对照组和观察组,各37例。对照组单用PCI治疗,观察组采用冠状动脉内溶栓联合PCI治疗。比较两组患者治疗前后血流分级情况、血清miRNA序列、心功能指标以及不良反应发生情况。结果:治疗后,观察组患者急性心肌梗死溶栓评分(TIMI)血流分级优于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者miRNA-210、miRNA-146a均低于对照组,miRNA-214、miRNA-155均高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者左心室舒张末期容积指数(LVEDVI)、左心室收缩末期容积指数(LVESVI)均低于对照组,左心室射血分数(LVEF)水平高于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:冠状动脉内溶栓联合PCI治疗AMI能够进一步调节miRNA序列水平,改善患者血流分级及心功能。Objective To observe the effect of intracoronary thrombolysis combined with percutaneous coronary intervention(PCI)on serum micro ribonucleic acid(miRNA)sequence and clinical indicators in patients with acute myocardial infarction(AMI).Methods The data of 74 patients with AMI admitted to Hebi People's Hospital from January 2020 to January 2023 were selected and divided into a control group and an observation group according to different treatment schemes,with 37 cases in each group.The control group was treated with PCI alone,while the observation group was treated with intracoronary thrombolysis combined with PCI.The blood flow grading,serum miRNA sequence,cardiac function indicators,and incidence of adverse reactions were compared between the two groups of patients before and after treatment.Results After treatment,the thrombolysis in myocardial infarction(TIMI)blood flow grading of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the miRNA-210 and miRNA-146a levels in the observation group were lower than those of the control group,while miRNA-214 and miRNA-155 levels were higher than those of the control group,with statistically significant differences(P<0.05).After treatment,left ventricular end diastolic volume index(LVEDVI)and left ventricular end systolic volume index(LVESVI)in the observation group were lower than those of the control group,and left ventricular ejection fractions(LVEF)levels were higher than those of the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion Intracoronary thrombolysis combined with PCI in the treatment of AMI can further regulate miRNA sequence levels,improve patient blood flow grading and cardiac function.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 冠状动脉内溶栓 

分 类 号：R542.22[医药卫生—心血管疾病]