自拟三七参芪汤对稳定型心绞痛患者临床指标的影响  

Effect of Self-prepared Sanqi Shenqi Decoction on Clinical Indexes of Patients with Stable Angina Pectoris

作　　者：年文静 王润娟 NIAN Wen-jing;WANG Run-juan(The First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450000)

机构地区：[1]郑州大学第一附属医院,河南郑州450000

出　　处：《深圳中西医结合杂志》2023年第12期35-38,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨自拟三七参芪汤对稳定型心绞痛(SAP)患者临床指标的影响。方法:选取在郑州大学第一附属医院2021年1月至2022年12月接受治疗的94例SAP患者,按随机数字表法均分为常规组与汤剂组,各47例。常规组患者给予常规西药治疗,汤剂组患者在常规治疗的基础上应用自拟三七参芪汤治疗。比较两组患者治疗后临床症状指标、血脂水平、血流变指标、血流变速、血清学相关指标的变化情况。结果:治疗后,汤剂组患者心绞痛发作频率、发作持续时间、硝酸甘油用量均少于常规组,差异具有统计学意义(P<0.05);治疗后,汤剂组患者三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均低于常规组,差异具有统计学意义(P<0.05);治疗后,汤剂组患者全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)均低于常规组,冠状动脉血流速度(CFV)高于常规组,差异具有统计学意义(P<0.05);治疗后,汤剂组患者血清N末端B型利钠肽原(NT-proBNP)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)水平均低于常规组,一氧化氮(NO)水平高于常规组,差异具有统计学意义(P<0.05)。结论:自拟三七参芪汤能够进一步缓解SAP患者的临床症状。Objective To investigate the effect of Self-prepared Sanqi Shenqi decoction on clinical indexes of patients with stable angina pectoris(SAP).Methods A total of 94 SAP patients treated in The First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 were selected and divided into a conventional group and a decoction group according to random number table method,with 47 cases in each group.The conventional group was treated with conventional western medicine,and the decoction group was treated with Self-prepared Sanqi Shenqi decoction on the basis of conventional treatment.The changes of clinical symptom index,blood lipid level,blood rheology index,blood flow velocity and serological related index were compared between the two groups after treatment.Results After treatment,the frequency of angina pectoris attack,duration of attack and dosage of nitroglycerin in the decoction group were lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the levels of triglyceride(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)in the decoction group were lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,whole blood high tangential viscosity(HBV),whole blood low tangential viscosity(LBV)and plasma viscosity(PV)in the decoction group were lower than those in the conventional group,while coronary blood flow velocity(CFV)was higher than that in the conventional group,with statistical significance(P<0.05).After treatment,the serum levels of N-terminal B-type natriuretic peptide(NT-probNP),vascular endothelial growth factor(VEGF)and endothelin-1(ET-1)in the decoction group were lower than those in the conventional group,and the level of nitric oxide(NO)was higher than that in the conventional group,the differences were statistically significant(P<0.05).Conclusion Self-prepared Sanqi Shenqi decoction can further relieve the clinical symptoms of patients with

关 键 词：稳定型心绞痛 自拟三七参芪汤 气阴两虚 血瘀阻络 

分 类 号：R541.4[医药卫生—心血管疾病]