氨甲环酸注射液致肢体肌肉神经症状1例药学监护及文献分析  

Pharmaceutical Care and Literature Analysis of Neurological Symptoms of Limb Muscles Induced by Tranexamic Acid Injection:A Case Report

作　　者：魏义荣 曹建英[3] 刘卫国[4] WEI Yirong;CAO Jianying;LIU Weiguo(College of Traditional Chinese Medicine,Weifang Medical University,Weifang,Shandong,China 261053;Qingzhou Rongjun Hospital of Shan-dong,Weifang,Shandong,China 262550;Weifang Maternal and Child Health Care Hospital,Weifang,Shandong,China 261011;Affiliated Hospital of Weifang Medical University,Weifang,Shandong,China 261041)

机构地区：[1]潍坊医学院中医学院,山东潍坊261053 [2]山东省青州荣军医院,山东潍坊262550 [3]山东省潍坊市妇幼保健院,山东潍坊261011 [4]潍坊医学院附属医院,山东潍坊261041

出　　处：《中国药业》2023年第16期119-123,共5页China Pharmaceuticals

基　　金：山东省妇幼保健协会科技创新科研项目[鲁妇幼协发〔2021〕19号]。

摘　　要：目的为临床安全使用氨甲环酸注射剂提供参考。方法回顾性分析潍坊市妇幼保健院收治的1例异常子宫出血、重度贫血、子宫腺肌病患者的用药经过,并结合氨甲环酸注射液使用过程中出现的肢体肌肉神经症状不良反应的国内外文献(共14篇),分析该药品不良反应(ADR)的特点及发生原因。结果该例患者的肌肉神经症状为静脉滴注氨甲环酸注射液约40 min时出现,属速发型ADR。结合文献分析可知,该ADR发生原因可能与药品作用机制、滴注速率过快、给药途径不适宜、用药剂量过大及个体差异等有关,但国内相应药品说明书多未记载警示。对此,应加强用药后60 min内的用药监测,一旦出现痉挛、震颤、抽搐等症状,应立即停药,迅速评估并对症处理。结论临床应规范使用氨甲环酸注射剂,加强安全性监测及风险防控。相关企业也应及时完善药品说明书,警示用药风险,促进安全用药。Objective To provide a reference for the safe use of Tranexamic Acid Injection in clinical practice.Methods The medication information of a case of abnormal uterine bleeding,severe anemia and adenomyosis admitted to the Weifang Maternal and Child Health Care Hospital was retrospectively analyzed.The characteristics and causes of the adverse drug reaction(ADR)of neurological symptoms of limb muscles induced by Tranexamic Acid Injection were analyzed based on 14 literature at home and abroad.Results The muscle neurological symptoms of this patient occured about 40 min after intravenous drip of Tranexamic Acid Injection,which was a immediate ADR.According to literature analysis,the causes of ADR might be related to the drug mechanism,excessive administration speed,inappropriate administration route,overdosage and individual differences,but there was no warning recorded in most corresponding drug instructions in China.Therefore,monitoring within 60 min after medication should be strengthened.Once symptoms such as spasm,tremor and convulsion occured,drug withdrawal should be taken immediately,rapid evaluation and symptomatical treatment should be given.Conclusion We should standardize the use of Tranexamic Acid Injection in clinical practice,strengthen safety monitoring,risk prevention and control.Relevant enterprises should also timely improve drug instructions,warn against drug risks and promote safe medication.

关 键 词：氨甲环酸注射液 肢体肌肉神经症状 用药风险 药品不良反应 安全用药 

分 类 号：R969.3[医药卫生—药理学]