基于数据挖掘探讨藏成药治疗萨滞布病的遣方用药规律  

Medication Regularity of Tibetan Patent Medicines for gZav-Grib Disease Based on Data Mining

作　　者：张旭冉 周莉[1] 董兴鲁[1] 刘博文 臧书晗 朱丽虹 ZHANG Xuran;ZHOU Li;DONG Xinglu;LIU Bowen;ZANG Shuhan;ZHU Lihong(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学,北京100029

出　　处：《中西医结合心脑血管病杂志》2023年第16期2923-2928,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：中国民族医药学会科研项目(No.2019KYXM-M106-145)。

摘　　要：目的:分析藏成药治疗萨滞布病的组方配伍规律,挖掘核心药物,为藏医临床与科研提供参考。方法:收集2020年版《中国药典》《四部医典》等著作中治疗萨滞布病的藏医方剂,在中国知网检索相关文献进行筛选和补充。运用Microsoft Excel 2021、IBM SPSS Modeler 18.0和SPSS 26.0软件进行频数分析、Apriori关联规则分析和系统聚类分析,通过Cytoscape 3.8构建藏药核心复杂网络,提取核心药组。结果:共收集28首主治萨滞布病的藏医方剂,涉及中药156种,其中毒性藏药14种,铁棒锤是使用频次最多的毒性藏药。频次≥6次的高频药物有28种,包括诃子、肉豆蔻、沉香等,药性以凉、温为主,六味以苦、辛、甘味偏盛,三化味以苦化味为主。常用药组包括诃子-沉香(支持度64.29%,置信度94.44%)、沉香-肉豆蔻-诃子(支持度57.14%,置信度87.50%)等。核心药物为诃子、丁香、沉香、肉豆蔻、麝香、木香。聚类分析为6类。结论:藏医治疗萨滞布病采用温散祛隆、清除坏血、协调三因、兼顾脉管的治疗思路,组方配伍注重寒热同调、隆血并治、标本兼顾。Objective:To explore the medication regularity of Tibetan patent medicines for gZav-Grib disease.Methods:Tibetan patent medicines mainly for gZav-Grib disease were collected in the 2020 edition of the Chinese Pharmacopoeia,and the Four Medical Classics,etc.The relevant literature was obtained from the China National Knowledge Infrastructure for screening and supplementation.Frequency analysis,Apriori association rule analysis,and systematic cluster analysis were performed using Microsoft Excel 2021,IBM SPSS Modeler 18.0,and SPSS 26.0.The core drugs were extracted by constructing a complex network through Cytoscape 3.8.Results:A total of 156 Tibetan medicines were involved in 28 Tibetan patent medicines.14 of 156 Tibetan medicines were toxic,and the Aconitum pendulum was the popular toxic Tibetan medicine.There were 28 high-frequency drugs with frequency≥6 times,including Terminalia Chebula,Myristicae Semen,and Aquilariae Lignum Resinatum.The medicinal properties were mainly cool andwarm.The six flavors were prevalent with pungent,sweet,and bitter flavors.The three tastes after digestion were mainly bitter.The popular drug groups were Terminalia Chebula-Aquilariae Lignum Resinatum(64.29% support,94.44% confidence),Terminalia Chebula-Myristicae Semen-Aquilariae Lignum Resinatum(57.14% support,87.50% confidence).The core drugs were Terminalia Chebula,Myristicae Semen,Aquilariae Lignum Resinatum,Clove,Musk,and Aucklandiae Radix.The 21 high-frequency drugs were classified as 6 categories in the systematic cluster analysis.Conclusion:The treatment ideas of gZav-Grib disease was warming and dispersing long,removing bad blood,coordinating the three causes,and taking into account the vasculature.The combination of drugs focused on regulating both heat and cold,treating both blood and Long,and taking into account both the symptoms and the basic causes.

关 键 词：萨滞布病 藏成药 数据挖掘 用药规律 核心药物 

分 类 号：R29[医药卫生—民族医学]