不同时间间隔艾司氯胺酮预先给药对小儿外科患者丙泊酚注射痛的影响  

作　　者：叶国妹 陈依君 

机构地区：[1]杭州市儿童医院,310014

出　　处：《浙江临床医学》2023年第7期1070-1071,共2页Zhejiang Clinical Medical Journal

摘　　要：目的观察不同时间间隔艾司氯胺酮预先给药对儿童丙泊酚注射痛的影响。方法拟行静脉麻醉诱导的患儿90例,随机分为小剂量氯胺酮预先注射60 s组(A组,30例)、小剂量氯胺酮预先注射30 s组(B组,30例)和利多卡因预先注射组(C组,30例),三组预先给药后给予丙泊酚相同公斤体质量诱导剂量。记录丙泊酚注射痛评分及用药后血压、心率。结果A组丙泊酚注射痛评分为(0.167±0.46)分,B组为(0.167±0.40)分,C组为(1.12±1.03)分。A组与B组比较,差异无统计学意义(P>0.05)。与C组比较,A组和B组丙泊酚注射痛评分均明显降低(P<0.001)。三组在心率、收缩压和舒张压等方面比较差异均无统计学意义(P>0.05)。结论儿外科患者麻醉诱导时,艾司氯胺酮预先给药可快速、有效降低丙泊酚注射痛。Objective To observe the effect of different intervals of esketamine pre-administration on propofol injection pain.Methods Nighty children(3.3~10.5 years)who planned to receive intravenous anesthesia induction were randomly divided into three groups:the group A,the group B and the group C,who were preinjected with low dose ketamine for 60 seconds,preinjected with low dose esketamine for 30 seconds and preinjected with lidocaine.The pain score of propofol injection,blood pressure and heart rate after propofol injection were recorded.Results Propofol injection pain score in the group A was(0.167±0.46),in the group B was(0.167±0.40),and in the group C was(1.12±1.03).Comparing the group A and the group B,there was no significant difference(P>0.05).Compared with the group C,propofol injection pain scores were significantly lower in both groups A and B(P<0.001).The three groups showed no significant differences in heart rate,systolic blood pressure and diastolic blood pressure(P>0.05).Conclusion Esketamine can rapidly and effectively reduce the injection pain of propofol in pediatric surgery patients before anesthesia.

关 键 词：艾司氯胺酮 丙泊酚 小儿外科患者 注射痛 

分 类 号：R614[医药卫生—麻醉学]