纤维蛋白(原)降解产物/D-二聚体比值的临床应用探讨  

Exploration of the clinical application of FDP/DD ratio

作　　者：曾艳芬[1] 曹鹏驹 窦敏[2] ZENG Yanfen;CAO Pengju;DOU Min(Fujian Provincial Center for Clinical Laboratory,Fujian Provincial Hospital,Fuzhou,Fujian 350001,China)

机构地区：[1]福建省立医院福建省临床检验中心,福州350001 [2]福建省立医院检验科

出　　处：《福建医药杂志》2023年第4期16-19,共4页Fujian Medical Journal

摘　　要：目的 探讨纤维蛋白(原)降解产物(FDP)/纤维蛋白降解产物D-二聚体(DD)比值在不同检测系统的差异、对DIC高凝期的鉴别效能及对DD检测结果的干扰识别能力。方法 非DIC患者90例,同时在CS5100和STA-R-Evolution检测DD、FDP,计算FDP/DD比值;回顾分析20例DIC高凝期、20例DIC纤溶期,计算FDP/DD比值;另收集FDP/DD比值<1.7和FDP/DD比值2~3的标本各10例,分别检测原倍和1∶8稀释的DD结果,计算稀释前后FDP/DD比值。结果 90例非DIC患者两台仪器DD在中值组和高值组差异有统计学意义(P<0.05),FDP3组差异无统计学意义(P>0.05);FDP/DD3组差异均有统计学意义(P<0.05)。DIC高凝期组与非DIC组比较,差异有统计学意义(P<0.01);DIC高凝期组与纤溶组比较差异有统计学意义(P<0.01)。正常组1∶8稀释后中的DD、FDP/DD比值与原倍差异无统计学意义(P>0.05);干扰组1∶8稀释后DD、FDP/DD比值与原倍比较,差异有统计学意义(P<0.05)。结论 FDP/DD比值在两种检测系统的差异有统计学意义;能为临床DIC早期高凝阶段的诊断提供帮助;能有效识别DD检测干扰。Objective To explore the difference of FDP/DD ratio in different detection systems,the discriminating efficiency of highcoagulation stage of DIC and the ability of interference identification of DD detection results.Methods A total of 90 inpatients with non-DIC were collected,at the same time,DD and FDP were detected by CS5100 and STA-R-E-vdution,and the FDP/DD ratio was calculated.According to the test results of TAT,PIC,Fib,Plt and thromboelastography,20 cases of DIC hypercoagulable phase and 20 cases of DIC fibrinolytic phase were selected to calculate the FDP/DD ratio.In addition,10 cases with FDP/DD ratio<1.7 and 10 inpatients with FDP/DD ratio 2-3 were collected.The DD results of primary dilution and 1∶8 dilution were detected respectively,and the FDP/DD ratio before and after dilution was calculated.Results In 90 non-DIC patients,there was a significant difference in DD between the median group and the high group(P<0.05),but there was no significant difference in FDP among the three groups(P>0.05).There were significant differences in FDP/DD among the three groups(P<0.05).There was significant difference between DIC hypercoagulable group and non-DIC group(P<0.01).There was significant difference between the DIC high coagulation stage group and fibrinolysis group(P<0.01).There was no significant difference in DD and FDP/DD ratio between 1∶8 dilution and original fold in normal group(P>0.05).There were significant differences in DD and FDP/DD ratio between the interference group and the original ratio after 1∶8 dilution(P<0.05).Conclusion FDP/DD ratio is significantly different between the two detection systems,which can provide meaningful help for the diagnosis of early hypercoagulablestage of DIC and effectively identify the interference of DD detection.

关 键 词：D-二聚体 FDP FDP/DD比值 临床应用 

分 类 号：R34[医药卫生—基础医学]