Histone variants:making structurally and functionally divergent nucleosomes and linkers in chromatin  

作　　者：Leilei SHI Yuda FANG 

机构地区：[1]National Key Laboratory of Plant Molecular Genetics,Shanghai Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Frontiers in Biology》2011年第2期93-101,共9页生物学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.91019006 to Y.F.);the Chinese Academy of Sciences(No.KSCX2-YW-N-099 to Y.F.)。

摘　　要：In addition to the post-translational modifications of histone proteins,emerging literature suggests that the mosaic nucleosomes formed by incorporation of various histone variants provide another mechanism for modifying chromatin structure and function.The locally defined chromatin by histone variants is involved in transcriptional regulation,DNA repair,centromere packaging,maintenance of pericentromeric heterochromatin,stress responses,temperature sensing,development,and many other biological processes.Here,we review the universal histone variants in H2A,H3 and H1 families and their roles in epigenetics.

关 键 词：H2AX H2AZ H3.3 CenH3 H1 

分 类 号：Q75[生物学—分子生物学]