线粒体动力学在临床常见机体高能量代谢系统病变中作用的研究进展  

Research progress of effects of mitochondrial dynamics on energy metabolism-related diseases

作　　者：周怡乐 史懿 方浩 胡艳 ZHOU Yi-le;SHI Yi;FANG Hao;HU Yan(Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Institute of Clinical Science,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院麻醉科,上海200032 [2]复旦大学附属中山医院实验研究中心,上海200032

出　　处：《中国临床医学》2023年第3期525-533,共9页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81971863)。

摘　　要：线粒体作为机体内主要的能量提供细胞器,自身主要通过线粒体动力学,即融合和分裂过程以及线粒体自噬来维持平衡,功能异常的线粒体堆积会导致细胞凋亡和对能量代谢高度需求的组织器官损害。本文主要阐述线粒体动力学及其改变对于临床常见能量代谢相关疾病的影响。Mitochondria,as the main energy supply organelles in the body,maintain balance mainly through mitochondrial dynamics—fusion and division process and mitochondrial autophagy.The accumulation of dysfunctional mitochondria will lead to cell apoptosis and damage of tissues and organs with high demand for energy metabolism.This review focuses on mitochondrial dynamics and its impact on clinically common energy metabolism-related diseases.

关 键 词：线粒体动力学 能量代谢 神经系统疾病 糖尿病 心血管疾病 

分 类 号：R339.6[医药卫生—人体生理学]