AECOPD患者血清MnSOD、CuZnSOD变化及其与疾病转归的关系  

Changes of serum MnSOD and CuZnSOD in patients with AECOPD and their relationship with disease outcome

作　　者：曹启凤 刘永琴 杨楠 CAO Qifeng;LIU Yongqin;YANG Nan(Respiratory and Critical Care Medical Care Unit,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075061,China)

机构地区：[1]河北北方学院附属第一医院呼吸与危重症医学科监护病房,河北张家口075061

出　　处：《国际检验医学杂志》2023年第16期1934-1937,1943,共5页International Journal of Laboratory Medicine

基　　金：2020年度河北省医学科学研究课题计划(20200525)。

摘　　要：目的分析慢性阻塞性肺疾病急性加重期(AECOPD)患者血清锰超氧化物歧化酶(MnSOD)、铜锌超氧化物歧化酶(CuZnSOD)变化及其与疾病转归的关系。方法将2018年11月至2021年12月该院收治的120例AECOPD患者作为AECOPD组,同期75例慢性阻塞性肺疾病稳定期患者作为稳定期组,另选取在该院体检的健康者60例作为对照组。所有AECOPD患者出院后随访1年,AECOPD组根据疾病转归情况分为好转组(n=84),恶化组(n=36)。所有纳入对象入院后均检测血清MnSOD、CuZnSOD水平,比较各组血清MnSOD、CuZnSOD水平变化。采用受试者工作特性曲线(ROC)评估血清MnSOD、CuZnSOD对AECOPD患者疾病转归的预测价值。结果AECOPD组血清MnSOD水平明显低于稳定期组、对照组,血清CuZnSOD水平明显高于稳定期组、对照组,差异有统计学意义(P<0.05)。恶化组血清MnSOD水平明显低于好转组,血清CuZnSOD水平明显高于好转组,差异有统计学意义(P<0.05)。ROC曲线分析显示,血清MnSOD预测AECOPD患者疾病转归的曲线下面积(AUC)为0.874,截断值5.58 U/mL,灵敏度、特异度分别为80.56%、78.57%,血清CuZnSOD预测AECOPD患者疾病转归的AUC为0.845,截断值66.62 U/mL,灵敏度、特异度分别为83.33%、70.32%。结论AECOPD患者血清MnSOD水平降低,CuZnSOD水平升高,二者与患者疾病转归密切相关,在诊断AECOPD患者疾病转归中具有良好的效能。Objective To explore the changes of serum manganese-containing superoxide dismutase(MnSOD) and copper-and zinc-containing superoxide dismutase(CuZnSOD) in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and their relationship with disease outcome.Methods Totally 120 AECOPD cases admitted to a hospital from November 2018 to December 2021 were taken as the AECOPD group,75 cases with chronic obstructive pulmonary disease in stable phase were taken as the stable phase group,and 60 healthy people in a hospital for health examination were taken as the control group.All AECOPD patients were followed up for 1 year after discharge.The AECOPD group was divided into improvement group(n=84) and deterioration group(n=36) according to the disease outcome.All the subjects were tested for serum MnSOD and CuZnSOD levels after admission,and the changes of serum MnSOD and CuZnSOD levels in each group were compared.The predictive value of serum MnSOD and CuZnSOD in disease outcome of AECOPD patients was evaluated by receiver operating characteristic(ROC) curve.Results The serum MnSOD level in AECOPD group was significantly lower than that in stable phase group and control group,and the serum CuZnSOD level was significantly higher than that in stable phase group and control group,the difference was statistically significant(P<0.05).The serum MnSOD level in the worsening group was significantly lower than that in the improving group,and the serum CuZnSOD level was significantly higher than that in the improving group,with statistical significance(P<0.05).The ROC curve analysis showed that the area under the curve(AUC) of serum MnSOD predicting the disease outcome of AECOPD patients was 0.874,the cut-off value was 5.58 U/mL,the sensitivity and specificity were 80.56% and 78.57% respectively,and the AUC of serum CuZnSOD predicting the disease outcome of AECOPD patients was 0.845,the cut-off value was 66.62 U/mL,the sensitivity and specificity were 83.33% and 70.32% respectively.Conclusion The decrease o

关 键 词：慢性阻塞性肺疾病急性加重期 锰超氧化物歧化酶 铜锌超氧化物歧化酶 疾病转归 

分 类 号：R563.9[医药卫生—呼吸系统]