铁代谢异常在中枢神经系统疾病中的研究进展  

Research progress of abnormal iron metabolism in central nervous system diseases

作　　者：黄云 双丽燕 黄志华[2,3] 江丽霞[2,4] HUANG Yun;SHUANG Li-yan;HUANG Zhi-hua;JIANG Li-xia(The First Clinical Medical School of Gannan Medical University;Key Laboratory of Ministry of Education for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Gannan Medical University;School of Basic Medicine,Gannan Medical University;Clinical Laboratory of the First Affiliated Hospital,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院第一临床医学院 [2]赣南医学院心脑血管疾病防治教育部重点实验室 [3]赣南医学院基础医学院 [4]赣南医学院第一附属医院检验科,江西赣州341000

出　　处：《赣南医学院学报》2023年第6期641-646,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(81760654,31960190);心脑血管疾病防治教育部重点实验室开放课题(XN201811,XN201921);江西省自然科学基金项目(20192BAB205117);江西省教育厅科技项目(GJJ170870);赣南医学院创新团队项目(TD20170)。

摘　　要：铁在人体中起着至关重要的作用,参与了中枢神经系统中多种重要的代谢过程。越来越多的证据表明,铁代谢紊乱在中枢系统疾病中起着重要作用。当中枢神经系统中的铁代谢失调,引起细胞内铁超载,导致细胞产生氧化应激、炎症等反应,甚至诱导铁死亡。因此,阐明铁代谢紊乱在中枢神经系统疾病当中的作用机制对今后治疗以及预防中枢神经系统疾病有着重要的意义。本文对正常的铁代谢、中枢神经系统疾病中的异常铁代谢及其因素进行综述。Iron plays a vital role in the human body.In the central nervous system,it is involved in many important metabolic processes.More and more evidences have suggested that iron metabolism disorders play an important role in central system diseases.When iron metabolism in the central nervous system is maladjusted,it will cause intracellular overload leading to oxidative stress,inflammation and other reactions in cells,and even inducing iron death.Therefore,it is of great significance for future treatment and prevention of central nervous system diseases by elucidating the mechanism of iron metabolism disorder in central nervous system diseases.This article intends to review the normal iron metabolism,abnormal iron metabolism and the related factors in central nervous system diseases.

关 键 词：铁代谢 中枢神经系统疾病 铁超载 

分 类 号：R338.25[医药卫生—人体生理学]