表没食子儿茶素没食子酸酯药动学及其药物相互作用研究进展  

Research progress in pharmacokinetics and drug interactions of epigallocatechin gallate

作　　者：陈思文 吕月 张凯娜 CHEN Siwen;LYU Yue;ZHANG Kaina(Gastroenterology Department,National Geriatric Disease Clinical Medicine Research Center,Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;The 3^(rd)Health Care Department,Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Pharmacology,School of Basic Medical Sciences,Xi′an Jiaotong University Health Science Center,Xi′an 710061,China)

机构地区：[1]中国人民解放军总医院第二医学中心消化内科,国家老年疾病临床医学研究中心,北京100853 [2]中国人民解放军总医院第二医学中心保健三科,北京100853 [3]西安交通大学医学部基础医学院药理学系,陕西西安710061

出　　处：《中国药理学与毒理学杂志》2023年第8期631-639,共9页Chinese Journal of Pharmacology and Toxicology

基　　金：海南省科技厅科技兴海专项(2015XH05)。

摘　　要：表没食子儿茶素没食子酸酯(EGCG)是茶多酚中主要的生物活性物质,有良好的临床应用前景。但是EGCG口服生物利用度差,大部分进入肠道,经尿便排泄;静脉给药后主要分布在肝、肺和小肠;对多种肝药物代谢酶和药物转运蛋白的活性有抑制作用,临床上应注意EGCG和相关药物的相互作用。本文结合EGCG的药动学特点,阐述EGCG对肝药物代谢和药物相互作用的影响,为EGCG的临床应用提供参考依据。Epigallocatechin gallate(EGCG)is the main bioactive substance in tea polyphenols,which has good prospects of clinical application.However,the oral bioavailability of EGCG is poor in that most of it enters the intestines and is excreted through urine and feces.After intravenous administration,it is mainly distributed in the liver,lung,and small intestines.It can inhibit the activities of several liver drug metabolism enzymes and drug transporters.In clinical practice,the interactions between EGCG and related drugs deserves attention.Based on the pharmacokinetic characteristics of EGCG,this article reviews the research progress in the effects of EGCG on drug metabolism and drug interaction in the liver in hopes of providing reference for clinical applications of EGCG.

关 键 词：表没食子儿茶素没食子酸酯 药动学 药物相互作用 药物代谢酶 

分 类 号：R969[医药卫生—药理学]