低分子肝素治疗胎盘脐带因素FGR的临床研究  

Clinical Study of Low Molecular Weight Heparin in the Treatment of Placental Cord Factor FGR

作　　者：廖小云 LIAO Xiaoyun(Department of Obstetrics and Gynecology,Anxi County Hospital,Anxi 362400,China)

机构地区：[1]安溪县医院产科,福建安溪362400

出　　处：《中国医药指南》2023年第23期53-56,共4页Guide of China Medicine

摘　　要：目的 探讨低分子肝素治疗胎盘脐带因素胎儿宫内生长受限(FGR)的临床效果。方法 选取2021年1月至2023年4月我院收治的胎盘脐带因素FGR孕妇92例,根据入院顺序将其分为两组,对照组予以补钙补铁及加强营养治疗,观察组予以低分子肝素联合阿司匹林、补钙补铁及加强营养治疗。比较两组的治疗效果、胎儿生长发育情况、血流参数情况、孕妇瘦素(Lep)、血清胰岛素样生长因子-1(IGF-1)、新生儿不良结局。结果 观察组治疗效果高于对照组(P <0.05);观察组胎儿头围、双顶径、宫高大于对照组(P <0.05);观察组RI、PI、S/D大于对照组(P <0.05);观察组孕妇Lep、IGF-1水平高于对照组(P <0.05);观察组新生儿不良结局少于对照组(P <0.05)。结论 低分子肝素治疗胎盘脐带因素FGR临床效果较好,可对母婴结局进行改善,应用价值较高。Objective To investigate the clinical effect of low molecular weight heparin in the treatment of placental cord factor FGR.Methods Ninetytwo pregnant women with fetal intrauterine growth restriction(FGR) due to placental cord factors admitted to our hospital from January 2021 to December 2022 were selected and divided into two groups according to the order of admission:control group:compound amino acid combined with dextran treatment,observation group:low molecular weight heparin combined with aspirin treatment.The therapeutic effect,fetal growth and development,blood flow parameters,maternal leptin(Lep),serum insulin-like growth factor-1(IGF-1) and neonatal adverse outcomes were compared between the two groups.Results The therapeutic effect of observation group was higher than that of control group(P<0.05).Fetal head circumference,double parietal diameter and uterine height in observation group were higher than those in control group(P<0.05).RI,PI and S/D in the observation group were higher than those in the control group(P<0.05).The levels of Lep and IGF-1 in the observation group were higher than those in the control group(P<0.05).The neonatal adverse outcome in the observation group was less than that in the control group(P<0.05).Conclusion Low molecular weight heparin in the treatment of placental cord factor FGR has good clinical effect,can improve the outcome of maternal and infant,and has high application value.

关 键 词：胎儿宫内生长受限 低分子肝素 阿司匹林 胎盘脐带因素 生长发育 血流参数 母婴结局 

分 类 号：R714.431[医药卫生—妇产科学]