来曲唑联合克罗米芬治疗多囊卵巢综合征患者的临床疗效及对其排卵和妊娠情况的影响  

Clinical Efficacy of Letrozole Combined with Clomiphene in the Treatment of Polycystic Ovary Syndrome and Its Influence on Ovulation and Pregnancy

作　　者：许冬晨 XU Dongchen(Department of Obstetrics and Gynecology,Hui'an County Hospital,Quanzhou 362100,China)

机构地区：[1]泉州市惠安县医院妇产科,福建惠安362100

出　　处：《中国医药指南》2023年第23期94-96,共3页Guide of China Medicine

摘　　要：目的 探讨来曲唑联合克罗米芬治疗多囊卵巢综合征(PCOS)患者的临床疗效及对排卵、妊娠情况的影响。方法 选取本院2021年1月至2022年1月收治的74例PCOS患者为研究对象,以统计学软件将患者分成观察、对照两组,各37例。对照组在月经第5日采用克罗米芬治疗5 d,观察组在月经第5日采用来曲唑治疗5 d。对比两组患者治疗性激素变化、子宫内膜功能与排卵情况、妊娠情况、并发症发生情况。结果 治疗前两组性激素指标T、LH、FSH、E2对比差异无统计学意义(P> 0.05);治疗后观察组性激素指标LH、FSH指标高于对照组(P <0.05)。治疗后观察组子宫内膜厚度、宫颈黏液评分、成熟卵泡数、宫腔容积、成熟卵泡平均直径均大于对照组(P <0.05)。观察组妊娠率高于对照组,但对比差异无统计学意义(P> 0.05);观察组孕周时间长于对照组,但对比差异无统计学意义(P> 0.05)。观察组卵巢过度刺激综合征(OHSS)、未破裂卵泡黄素化综合征(LUFS)总发生率低于对照组(P <0.05)。结论 来曲唑在治疗PCOS中的疗效好于克罗米芬,可促进患者性激素水平调节,改善卵巢功能,促进排卵,对提升妊娠率有一定价值。Objective To investigate the clinical efficacy of letrozole combined with clomiphene in the treatment of polycystic ovary syndrome(PCOS)and its influence on ovulation and pregnancy.Methods A total of 74 patients with PCOS admitted to our hospital from January 2021 to January 2022 were selected as the study subjects,and the patients were divided into observation and control groups with statistical software,37 patients in each group.The control group was treated with clomiphene for 5 days on the 5th day of menstruation,and the observation group was treated with letrozole for 5 days on the 5th day of menstruation.The changes of sex hormones,endometrial function and ovulation,pregnancy and complications were compared between the two groups.Results Before treatment,there was no significant difference between the two groups in sex hormone indexes T,LH,FSH and E2(P>0.05).After treatment,the indexes of LH and FSH in the observation group were higher than those in the control group(P<0.05).After treatment,the thickness of endometrium,score of cervical mucus,number of mature follicles,volume of uterine cavity and average diameter of mature follicles in the observation group were greater than those in the control group(P<0.05).The pregnancy rate in the observation group was higher than that in the control group,but the difference was not significant(P>0.05).The gestational weeks in the observation group were longer than those in the control group,but the difference was not significant(P>0.05).The total incidence of ovarian hyperstimulation syndrome(OHSS)and luteinized unruptured follicle syndrome(LUFS)in the observation group was lower than that in the control group(P<0.05).Conclusion Letrozole is better than clomiphene in the treatment of PCOS.It can promote the regulation of sexual hormone level,improve ovarian function,promote ovulation,and has certain value in promoting pregnancy rate.

关 键 词：多囊卵巢综合征 妇科疾病 排卵功能 卵巢功能 来曲唑 克罗米芬 

分 类 号：R271.1[医药卫生—中医妇科学]