干扰素、保妇康栓治疗宫颈上皮内瘤变1级与人乳头瘤病毒感染的效果分析  

Effect Analysis of Interferon and Baofukang Suppository in the Treatment of CIN1 and HPV Infections

作　　者：孙秀云 SUN Xiuyun(Department of Women's Health,Maternal and Child Health Hospital,Family Planning Service Center,Boshan District,Zibo 255200,China)

机构地区：[1]山东省淄博市博山区计划生育服务中心区妇幼保健院妇女保健科,山东淄博255200

出　　处：《中国医药指南》2023年第23期131-133,共3页Guide of China Medicine

摘　　要：目的 统计分析干扰素、保妇康栓治疗宫颈上皮内瘤变(CIN)1级与人乳头瘤病毒(HPV)感染的有效性、安全性及其对人体生理状态的影响。方法 本研究从2020年2月至2023年1月入院治疗的CIN 1级与HPV感染患者中随机抽调120例作为研究对象,参照等分原则将其分为对照组、观察组,每组60例,对照组以重组人干扰素α-2b阴道泡腾片治疗,观察组以干扰素、保妇康栓联合治疗,比较两组治疗效果、血清学炎性因子指标及不良反应发生情况。结果 观察组治疗总有效率为93.33%,对照组治疗总有效率为80.00%,差异有统计学意义(P <0.05);观察组TNF-α、Hs-CRP、IL-6指标低于对照组,差异有统计学意义(P <0.05);观察组不良反应发生率为10.00%,对照组不良反应发生率为11.67%,差异无统计学意义(P> 0.05)。结论 干扰素和保妇康栓方案用于CIN 1级与HPV感染的临床治疗中的整体有效性更高,且不良反应控制效果更好,可以作为临床首选的治疗方案。Objective To statistically analyze the efficacy and safety of interferon and Baofukang suppository in the treatment of cervical intraepithelial neoplasia(CIN)grade 1 and human papillomavirus(HPV)infection,as well as their impact on human physiological status.Methods This study used the period from February 2020 to January 2023 as the basis for case data collection.Among the CIN1 and HPV infected patients admitted to hospital during the period,120 cases were randomly selected as the study subjects,and they were compared and divided into observation groups according to the principle of equal division,60 cases were all set up,and recombinant human interferon was used for treatmentα-2b vaginal effervescent tablets were used as the treatment plan for the control group,and interferon and Baofukang suppository were used as the treatment plan for the observation group.The therapeutic effects,serological inflammatory factor indicators,and adverse reactions of the two groups were compared.Results The effective rate of treatment in the observation group was 93.33%,while the effective rate of treatment in the control group was 80.00%.It can be seen that the effective rate of treatment in the observation group was higher than that in the control group,with a significant difference(P<0.05).The values of TNF-α,Hs-CRP,IL-6 and other indicators in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 10.00%,while the incidence of adverse reactions in the control group was 11.67%.Therefore,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Interferon and Baofukang Suppository have higher overall effectiveness and better adverse reaction control effects when used in the clinical treatment of CIN1 and HPV infections.They can be used as the first choice in clinical treatment.

关 键 词：宫颈上皮内瘤变 人乳头瘤病毒 干扰素 保妇康栓 血清学炎性因子 

分 类 号：R711.74[医药卫生—妇产科学]