肠道微生物群与儿童厌食发病机制的研究进展  

The role of the gut microbiome in the pathogenesis of childhood anorexia

作　　者：段云雁[1] DUAN Yunyan(Department of Pediatrics,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430074,China)

机构地区：[1]湖北省中医院光谷院区儿科,湖北武汉430074

出　　处：《医药前沿》2023年第16期54-58,共5页Journal of Frontiers of Medicine

摘　　要：儿童“厌食”因为存在行为改变,被西医学归为精神疾病。厌食可出现多种并发症,营养不良、生长发育迟缓、闭经、矮身材等。厌食还常与抑郁症、焦虑症等其他精神障碍共见。因其发病机理复杂,西医循证治疗方案有限,迫切需要新的治疗方法。有学者认为厌食涉及大脑与肠道微生物群及内分泌系统和免疫系统的相互作用。厌食伴随着肠道微生物群及其代谢产物的改变,该改变进一步影响食欲和摄食行为。本文就当前肠道微生物群与儿童厌食发病机制的研究进展做一综述,以期为儿童厌食的治疗提供新的思路。Childhood anorexia is classified as a psychiatric disorder in Western medicine due to behavioral changes.Anorexia is associated with a variety of health problems,such as malnutrition,retarded growth and development,amenorrhea,or short stature.Anorexia frequently co-occurs with other psychiatric disorders,such as anxiety and depression.There is limited evidence-based treatment available for patients with anorexia,and novel therapeutic approaches are urgently needed due to the complex pathogenesis.Some researchers believe that the origin of anorexia may involve interactions with the endocrine and immune systems,as well as the gut microbiota.Anorexia is associated with changes in the gut microbiota and microbial metabolites;Such changes further affect appetite and feeding behavior.The advances in the study of the relationship between the gut microbiome and childhood anorexia are reviewed to offer new perspectives.

关 键 词：儿童厌食 肠道微生物群 食欲调节 心境调节 

分 类 号：R442.1[医药卫生—诊断学]