早期微量喂养联合益生菌治疗新生儿喂养不耐受的疗效观察  

Effect of early micro feeding combined with intestinal probiotics for treating neonates with feeding intolerance

作　　者：曾峰[1] 柯欢[1] 戴胜亚 史荣梅 程锐[2] ZENG Feng;KE Huan;DAI Shengya;SHI Rongmei;CHENG Rui(Xuancheng Central Hospital,Anhui Province,242000;Children's Hospital Affiliated to Nanjing Medical University)

机构地区：[1]安徽省宣城市中心医院,242000 [2]南京医科大学附属儿童医院

出　　处：《中国计划生育学杂志》2023年第8期1867-1871,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨早期微量喂养联合益生菌治疗新生儿喂养不耐受临床疗效。方法:选取2020年1月-2022年2月本院收治的喂养不耐受新生儿90例,随机数字表法分为观察组和对照组各45例,对照组采用常规喂养,观察组采用早期微量喂养联合益生菌治疗。观察和记录两组治疗效果,并检测两组治疗前后血生化指标。结果:治疗后观察组呕吐停止(2.7±0.7d)、腹胀消失(2.8±0.9d)、达全胃肠道喂养(6.7±1.6d)、恢复出生体重(5.4±1.2d)和住院等时间(12.9±1.7d)均短于对照组(3.6±0.9d、4.0±1.2d、7.9±1.7d、6.0±1.3d、14.6±2.0d),两组血清学指标均有改善,且观察组血清总胆红素(81.43±27.12μmol/L)低于对照组(107.75±32.08μmol/L),白蛋白(43.08±10.25 g/L)和前白蛋白(18.65±1.25 mg/dl)水平高于对照组(36.34±9.20 g/L、13.40±1.15 mg/dl)(均P<0.05)。结论:早期微量喂养联合益生菌治疗新生儿喂养不耐受,可有效促进患儿胃肠道成熟,缩短肠外营养时间,改善血生化中营养学指标。Objective:To explore the elinical efficacy of early micro feeding combined with intestinal probiotics for trea-ting neonates with feeding intolerance.Methods:90 neonates with feeding intolerance were selected and were divided into two groups(45 cases in each group)according to the random number table method from January 2020 to February 2022.The neonates in the control group were trcated with routine feeding,and the neonates in the study group were treated with carly micro feeding combined with intestinal probiotics.The treatment effect of the neonates in the two groups were observed and recorded.The values of the serum biochemical indexed of the neonates in the two groups be-fore and after tratment were detected.Results:After treatment,the durations of vomiting(2.7±0.7d),the abdomi-nal distension(2.8±0.9d),and the total gastrointestinal feeding(6.7±1.6d),the time to the recovery of birth weight(5.4±1.2d),and the hospitalization time(12.9±1.7d)of the neonates in the study group were significantly shorter than those(3.6±0.9d,4.0±1.2d。7.9±1.7 d,6.0±1.3d,and 14.6±2.0 d)of the neonates in the control group.The serological indexes of the neonates in both groups after treatment had improved significantly.The levels of serum total bilirubin(81.43±27.12μmol/L)of the neonates in the study group was significantly lower than that(107.75±32.08μmol/L)of the neonates in the control group.The levels of albumin(43.08±10.25 g/L)and prealbumin(18.65±1.25 mg/d)of the neonates in the study group were significantly higher than those(36.34±9.20 g/L and 13.40±1.15 mg/dl)of the neonates in the control group(all P<0.05).Conclusion:Early microfeeding combined with intestinal probi-otics for treating the neonates with feeding intolerance can effectively promote the maturation of their gastrointestinal tract,shorten the time of their parenteral nutrition,and improve their nutritional indicators of the serum biochemistry detection.

关 键 词：新生儿 喂养不耐受 早期微量喂养 肠道益生菌 血生化营养学指标 效果 

分 类 号：R722.1[医药卫生—儿科]