妊娠期糖尿病患者血清PAPP-A、SHBG水平与膳食抗炎指数和产后血糖转归关系  

Correlation between serum pregnancy-associated protein A and sex hormone binding globulin of women with gestational diabetes mellitus and their dietary anti-inflammatory index value and change of postpartum blood glucose level

作　　者：李桂花 廖丹 王玲[2] 郑珍珍 LI Guihua;LIAO Dan;WANG Ling;ZHENG Zhenzhen(Hainan Modern Women and Children's Hospital,Haikou,Hainan Province,570311;Hainan People Hospital(Hainan Hospital Affiliated to Hainan Medical University),Haikou)

机构地区：[1]海南现代妇女儿童医院,海口570311 [2]海南省人民医院(海南医学院附属海南医院)

出　　处：《中国计划生育学杂志》2023年第8期1931-1934,1938,共5页Chinese Journal of Family Planning

基　　金：2022年海南省卫生计生行业科研项目(22A200111)。

摘　　要：目的:探究妊娠期糖尿病(GDM)孕妇血清妊娠相关蛋白A(PAPP-A)和性激素结合球蛋白(SHBG)水平与膳食抗炎指数和产后血糖转归的关系。方法:选择2019年5月1日-2022年5月1日在本院分娩的GDM产妇118例为观察组,正常孕产妇120例为对照组,比较两组及不同膳食抗炎指数、不同产后血糖转归GDM患者PAPP-A、SHBG水平,并分析血清PAPP-A、SHBG水平与膳食抗炎指数和产后血糖转归的关系。结果:PAPP-A、SHBG水平,观察组(245.41±3.25 ng/L、26.97±3.37 mmol/L)均低于对照组(296.71±3.14 ng/L、44.41±3.06 mmol/L),且观察组中抗炎倾向组、中间组以及促炎倾向组水平逐渐降低,分娩后血糖异常组低于血糖转归组,观察组产后血糖异常以及DII促炎倾向与血清PAPP-A、SHBG水平均呈负相关(均P<0.05)。结论:GDM孕妇血清PAPP-A、SHBG水平异常降低,与膳食抗炎指数和产后血糖转归具有相关性。Objective:To study the correlation between the levels of serum pregnancyrassocited protein A(PAPP-A)and sex hormone binding globulin(SHBG)of pregnant women with gestational diabetes mellitus and dietary anti-in-flammatory index value and their change of postpartum blood glucose level.Methods:118 pregnant women with GDM were selected in observation group,and 120 normal pregnant women were selected in control group from May 1,2019 to May 1,2022.The serum PAPPA and SHBG levels and the different dietary anti inflammatory index value of the women were compared between the two groups.The serum PAPP A and SHBG levels were also compared among the women with different change of postpartum blood glucose levels.The correlation between the serum PAPP-A and SH-BG levels of the women and their dietary anti inflammatory index value and change of postpartum blood glucose level was analyzed.Results:The levels of PAPPA(245.41+3.25 ng/L)and SHBG(26.97±3.37 mmol/L)of the women in the observation group were significantly lower than those(296.71±3.14 ng/L and 44.41±3.06 mmol/L)of the women in the control group.In the observation group,the levels of PAPP-A and SHBG of the women with mild antir inflammatory tendency.of the women with anti-inflammatory tendency.and the women with pro-inflammatory tend-ency had deereased gradually.The lewels of PAPP-A and SHBG of the women with the abnormal postpartum blood.glucose level were signifiantly lower than those of the women with the normal postpartum blood glucose level.In the observation group.the abnormal blood glucose level and the pror inflammatory tendency of DII of the women were neg-atively correlated with their serum PAPP-A and SHBG levels(all P<0.05).Conclusion:The serum PAPP-A and SH-BG levels of the pregnant women with GDM decrease abnormally,and which were significantly correlated with the di-ectary antir inflammatory index value and the change of postpartum blood glucose le of the women.

关 键 词：妊娠期糖尿病 妊娠相关蛋白 A 性激素结合球蛋白 膳食抗炎指数 产后血糖转归 相关性 

分 类 号：R714.256[医药卫生—妇产科学]