术前应用间苯三酚对绝经期节育器取出术效果的影响  

Effect of Preoperative Application of Phloroglucinol in Patients Undergoing Menopausal Intrauterine Device Removal

作　　者：吴晓华 曾玉红 王金萍 卢剑 WU Xiaohua;ZENG Yuhong;WANG Jinping;LU Jian(Ganxian District People's Hospital,Ganzhou Jiangxi 341100,China)

机构地区：[1]赣县区人民医院,江西赣州341100

出　　处：《药品评价》2023年第5期644-647,共4页Drug Evaluation

基　　金：赣州市科技计划项目(2022ZDX9873)。

摘　　要：目的探究术前应用间苯三酚对绝经期节育器取出术患者的效果。方法选择2020年3月至2022年6月于赣县区人民医院接受节育器取出术治疗的绝经后女性90例为研究对象,按照患者术前不同用药方案分成对照组、观察组,每组各45例。两组均接受节育器取出术治疗,对照组在术前予以米非司酮片口服治疗,之后直接开展取环术治疗;观察组在对照组基础上,术前30 min予以静脉注射40 mg间苯三酚,之后开展取环术治疗。对比分析两组手术指标、宫颈软化效果、镇痛效果、取环效果,并统计两组不良事件发生率。结果对照组手术时间(8.52±2.49)min长于观察组(3.57±1.10)min,术中失血量(15.46±3.37)mL多于观察组(9.18±2.25)mL,差异有统计学意义(P<0.05);观察组的宫颈软化总有效率95.56%(43/45),较对照组82.22%(37/45)高(P<0.05);观察组的镇痛总有效率84.44%(38/45),较对照组42.22%(19/45)高(P<0.05);观察组的取环总成功率97.78%(44/45),较对照组82.22%(37/45)高,差异有统计学意义(P<0.05);两组不良事件发生率对比,差异无统计学意义(P>0.05)。结论术前应用间苯三酚能更好地提升绝经期节育器取出术患者的宫颈软化效果和镇痛效果,提高取环成功率,可于临床推广。Objective To investigate the effect of preoperative application of phloroglucinol in patients undergoing menopausal intrauterine device removal.Methods A total of 90 postmenopausal women who received the intrauterine device removal in Ganxian District People's Hospital from March 2020 to June 2022 were selected as the study subjects,divided into control group and observation group according to different medication regimens of patients preoperatively,with 45 cases in each group.Both groups were treated with intrauterine device removal,patients in the control group were orally treated with mifepristone tablets before operation,after which the ring removal therapy was directly started;and patients in the observation group were simultaneously treated with intravenous injection of 40 mg phloroglucinol 30 min before operation,after which the ring removal therapy was started.The surgical indexes,cervical softening effect,analgesic effect,ring removal effect in the two groups were comparatively analyzed,and the incidence of adverse events in the two groups was counted.Results The operation time in the control group(8.52±2.49)min was longer than that in the observation group(3.57±1.10)min,and intraoperative blood loss(15.46±3.37)mL was more than the observation group(9.18±2.25)mL,with a significant difference(P<0.05);the overall effective rate of cervical softening was 95.56%(43/45)in the observation group,which was higher than that of 82.22%(37/45)in the control group(P<0.05);the total effective rate of analgesia was 84.44%(38/45)in the observation group,which was higher than that of 42.22%(19/45)in the control group(P<0.05);the total success rate of ring removal was 97.78%(44/45)in the observation group,which was higher than that of 82.22%(37/45)in the control group(P<0.05);there were no significant differences in the incidence of adverse events between the two groups(P>0.05).Conclusion Preoperative application of phloroglucinol can better improve the efficacy of cervical softening and analgesia in patients undergoi

关 键 词：宫内节育器取出术 装置取出 绝经期 间苯三酚 宫颈软化效果 镇痛 取环效果 

分 类 号：R713[医药卫生—妇产科学]