头孢哌酮钠舒巴坦钠联合阿卡波糖对老年糖尿病合并肺部感染患者CD64、CGRP表达的影响  

Effects of cefoperazone sodium and sulbactam sodium combined with acarbose on the expression of CD64 and CGRP in elderly patients with diabetes and pulmonary infection

作　　者：高照华 蔡若男[1] 王昭玲[1] 胡浩[1] 王勃[1] 孙进[1] 裴颖 刘媛媛 周婷婷[1] 尹雯雯 火焱 Gao Zhaohua;Cai Ruonan;Wang Zhaoling;Hu Hao;Wang Bo;Sun Jin;Pei Ying;Liu Yuanyuan;Zhou Tingting;Yin Wenwen;Huo Yan(Department of endocrinology,Xuzhou first people's hospital,Xuzhou,Jiangsu,221000,China)

机构地区：[1]徐州市第一人民医院内分泌科,江苏徐州221000

出　　处：《齐齐哈尔医学院学报》2023年第8期718-722,共5页Journal of Qiqihar Medical University

基　　金：徐州医科大学附属医院发展基金(XYFM2021037)。

摘　　要：目的探讨头孢哌酮钠舒巴坦钠联合阿卡波糖对老年糖尿病合并肺部感染患者CD64、CGRP表达的影响。方法选择2020年1月—2022年1月本院收治的98例老年糖尿病合并肺部感染患者作为研究对象,按照随机数表法分为对照组和研究组两组,每组各49例。对照组患者采用头孢哌酮钠舒巴坦钠进行治疗,研究组采用头孢哌酮钠舒巴坦钠、阿卡波糖联合治疗。检测两组患者的免疫功能指标、血清炎症因子、肺功能指标、内皮素(endothelin,ET)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)指标水平、临床症状改善时间、血糖控制情况对比及临床疗效。结果与治疗前相比,治疗后两组患者的CD8+、CD64、脑利钠肽(brain natriuretic peptide,BNP)、C反应蛋白(C reactive protein,CRP)、降钙素原(procalcitonin,PCT)、白细胞介素-6(Interleukin-6,IL-6)、ET指标水平均降低,CD3+、CD4+、用力呼气容积(forced expiratory volume,FEV1)、用力肺活量(forced vital capacity,FVC)、FEV1/FVC、CGRP指标水平升高,且研究组变化幅度较大,差异具有统计学意义(P<0.05)。与对照组相比,研究组临床症状改善时间较短,血糖控制情况和临床疗效较好,差异具有统计学意义(P<0.05)。结论头孢哌酮钠舒巴坦钠、阿卡波糖的联合治疗可以促进肺功能的恢复,使炎症因子指标趋于正常,有效控制血糖,提升患者的免疫功能,疗效显著。Objective To investigate the effects of cefoperazone sodium and sulbactam sodium combined with acarbose on the expression of CD64 and CGRP in elderly patients with diabetes and pulmonary infection.Methods A total of 98 elderly patients with diabetes and pulmonary infection who were treated in our hospital from January 2020 to January 2022 were selected as study subjects.According to the random number table method,the patients were divided into a control group and a study group,49 cases in each group.The control group was treated with cefoperazone sodium and sulbactam sodium,and the study group was treated with cefoperazone sodium and sulbactam sodium combined with acarbose.The immune function indexes,serum inflammatory factors,pulmonary function indexes,endothelin(ET)and calcitonin gene-related peptide(CGRP)indexes,clinical symptom improvement time and blood sugar control,and clinical efficacy of the two groups of patients were compared.Results Compared with those before treatment,the levels of CD8+,CD64,brain natriuretic peptide(BNP),C reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)and ET indexes were decreased in both two groups.The level of CD3+,CD4+,forced expiratory volume(FEV1),forced vital capacity(FVC),FEV1/FVC,CGRP index increased,and the change amplitude in the study group was higher than that in the control group,with a statistical difference(P<0.05).Compared with the control group,the improvement time of clinical symptoms in the study group was shorter,and the blood sugar control and clinical efficacy were better,with statistical difference(P<0.05).Conclusions The combined treatment of cefoperazone sodium sulbactam sodium and acarbose can promote the recovery of lung function,make the inflammatory factor indicators tend to normal,effectively control the blood sugar level,and improve the patient's immune function,with significant curative effect.

关 键 词：头孢哌酮钠舒巴坦钠 阿卡波糖 老年糖尿病合并肺部感染 免疫功能 肺功能 

分 类 号：R587.1[医药卫生—内分泌]