磁性羟基磷灰石晶须的制备及其在磁场下的磁响应行为研究  

Synthesis of Magnetized Hydroxyapatite Whisker and Its Magnetic Response Behavior Under Magnetic Field

作　　者：钏定泽 颜廷亭 刘继涛 CHUAN Dingze;YAN Tingting;LIU Jitao(Yunnan Baiyao Group Health Products Co.,Ltd.,Kunming 650217,China;Faculty of Materials Science and Engineering,Kunming University of Science and Technology,Kunming 650093,China)

机构地区：[1]云南白药集团健康产品有限公司,昆明650217 [2]昆明理工大学材料科学与工程学院,昆明650093

出　　处：《人工晶体学报》2023年第8期1532-1539,共8页Journal of Synthetic Crystals

基　　金：云南省杨雷院士专家工作站(202205AF15025)。

摘　　要：羟基磷灰石晶须(HAw)的定向是设计和开发生物陶瓷的关键之一。本研究采用水热法将磁性纳米粒子四氧化三铁(Fe_(3)O_(4))负载到HAw表面,成功制备出具有优良磁响应特性的磁性HAw复合材料,系统研究了磁化HAw的理化性能、生物学性能并探究了其在弱磁场中的取向行为。结果表明四氧化三铁(Fe_(3)O_(4))纳米粒子被成功负载到HAw表面,所制备的磁化HAw在室温下具备超顺磁性,且具有良好的磁响应特性,仅通过常规的永磁体就可以实现操控。结合磁场诱导注浆成型技术,由外部磁场施加的对准方向被有效固定。CCK-8实验结果表明磁化HAw不具有细胞毒性。The orientation of hydroxyapatite whiskers(HAw)is one of key to design and develop bioactive ceramics for bone regeneraction.Guided behavior based on the construction of magnetic anisotropy.In this study,magnetic nanoparticles Fe_(3)O_(4) were loaded onto the surface of HAw by hydrothermal method,and magnetic HAw composites with excellent magnetic response characteristics were successfully prepared.The physicochemical properties and biological properties of magnetized HAw were systematically studied,and its orientation behavior in weak magnetic field was explored.The results show that ferric oxide(Fe_(3)O_(4))nanoparticles are successfully loaded onto the surface of HAw,and the magnetized HAw has superparamagnetism and good magnetic response at room temperature,which can be manupulated by conventional permanent magnets.The alignment direction applied by the external magnetic field is effectively fixed by combining the magnetic field-induced grouting molding technology.The results of CCK-8 experiment show that magnetized HAw has no cytotoxicity.

关 键 词：羟基磷灰石 晶须 四氧化三铁 超顺磁性 定向 细胞毒性 

分 类 号：TQ174[化学工程—陶瓷工业]