行靶向联合系统穿刺PI-RADS评分3分患者确诊具有临床意义前列腺癌的危险因素及其预测效能  

Risk factors and predictive effectiveness of PI-RADS after targeted combined system puncture for CsPCa patients with 3 points

作　　者：胡伟强 甘为民 姚晓群[2] 何建光[1] 丁宁 刘坤龙 张刘勇[1] 王军平[2] 刘晖[2] HU Weiqiang;GAN Weimin;YAO Xiaoqun;HE Jianguang;DING Ning;LIU Kunlong;ZHANG Liuyong;WANG Junping;LIU Hui(Department of Urology,Xi’an Gaoxin Hospital,Xi’an 710077,China;Department of Radiology,Xi’an Gaoxin Hospital,Xi’an 710077,China)

机构地区：[1]西安高新医院泌尿外科,陕西西安710077 [2]西安高新医院放射科,陕西西安710077

出　　处：《现代泌尿外科杂志》2023年第8期692-695,共4页Journal of Modern Urology

摘　　要：目的 探讨行靶向联合系统穿刺前列腺影像报告和数据系统(PI-RADS)评分3分患者确诊具有临床意义前列腺癌(CsPCa)的危险因素及其预测效能,旨在为后续临床诊治工作提供更为充分的循证医学证据。方法 回顾性分析2017年1月-2021年12月于我院行靶向联合系统穿刺PI-RADS评分3分患者153例临床及多参数磁共振(mpMRI)检查资料,确定PI-RADS评分3分患者确诊CsPCa独立危险因素,评估相关独立危险因素用于确诊CsPCa预测临床效能。结果 单因素和多因素分析结果显示,血清前列腺特异性抗原(PSA)密度和表观弥散系数均是PI-RADS评分3分患者确诊CsPCa独立危险因素(P<0.05);受试者工作特征曲线(ROC)分析结果显示,PSA密度+表观弥散系数用于PI-RADS评分3分患者确诊CsPCa预测效能优于两者单用(P<0.05)。结论 PSA密度和表观弥散系数联合检测可指导临床医生从PI-RADS评分3分患者中识别CsPCa,确诊高危人群。Objective To investigate the risk factors and predictive effectiveness of prostate imaging reporting and data system(PI-RADS)score for patients with clinically significant prostate cancer(CsPCa)whose PI-RADS score was 3,so as to provide evidence for the diagnosis and treatment.Methods The clinical and multi-parameter magnetic resonance imaging(mpMRI)data of 153 CsPCa patients treated during Jan.2017 and Dec.2021 whose PI-RADS score was 3 were retrospectively analyzed.With PI-RADS score of 3 as the independent risk factor for CsPCa,the other relevant independent risk factors in predicting CsPCa were evaluated.Results Univariate and multivariate analyses showed that prostate-specific antigen(PSA)density and apparent dispersion coefficient(ADC)were independent risk factors for the diagnosis of CsPCa(P<0.05).Analysis of receiver operating characteristic(ROC)curve showed that combined PSA density and ADC were more effective than PSA density and ADC alone(P<0.05).Conclusion The combination of PSA density and ADC can guide clinicians to identify high-risk CsPCa patients from patients with PI-RADS score of 3 points.

关 键 词：穿刺 前列腺影像报告和数据系统 磁共振 具有临床意义前列腺癌 

分 类 号：R659[医药卫生—外科学]