妊娠期外阴阴道假丝酵母菌病联合应用克霉唑阴道片、乳杆菌活菌胶囊治疗的临床效果分析  

Analysis of the clinical effect of vulvovaginal candidiasis during pregnancy treated with clotrimazole vaginal tablets and live lactobacillus capsule

作　　者：张媛 白双 冯凯 ZHANG Yuan;BAI Shuang;FENG Kai(Department of Obstetrics,Maternal and Child Health Hospital of Dongchangfu District,Liaocheng 252000,China)

机构地区：[1]聊城市东昌府区妇幼保健院产科,252000 [2]聊城市东昌府区妇幼保健院妇科,252000

出　　处：《中国现代药物应用》2023年第15期29-33,共5页Chinese Journal of Modern Drug Application

摘　　要：目的探讨分析妊娠期外阴阴道假丝酵母菌病(VVC)联合应用克霉唑阴道片、乳杆菌活菌胶囊治疗的临床效果。方法70例妊娠期VVC患者,采用随机数字表法分为观察组和对照组,每组35例。对照组应用克霉唑阴道片治疗,观察组在对照组基础上联合应用乳杆菌活菌胶囊治疗。比较两组患者治疗效果、阴道分泌物指标、不良反应发生情况、症状改善时间、不良母婴结局发生情况、复发情况。结果观察组患者治疗总有效率为85.71%,高于对照组的62.86%,差异具有统计学意义(P<0.05)。治疗后,两组患者阴道分泌物肿瘤坏死因子-α、白细胞介素-6水平均低于本组治疗前,且观察组患者阴道分泌物肿瘤坏死因子-α(14.36±4.01)ng/ml、白细胞介素-6(26.11±7.22)ng/L低于对照组的(20.11±6.00)ng/ml、(38.45±6.99)ng/L,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为8.57%,低于对照组的28.57%,差异具有统计学意义(P<0.05)。观察组患者瘙痒、灼痛、分泌物异常改善时间均短于对照组,差异具有统计学意义(P<0.05)。观察组患者不良母婴结局发生率为5.71%,低于对照组的25.71%,差异具有统计学意义(P<0.05)。观察组患者复发率为2.86%,低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论妊娠期VVC联合应用克霉唑阴道片、乳杆菌活菌胶囊治疗效果理想,值得临床推广应用。Objective To discuss and analyze the clinical effect of vulvovaginal candidiasis(VVC)during pregnancy treated with clotrimazole vaginal tablets and live lactobacillus capsule.Methods A total of 70 cases of patients with VVC during pregnancy were divided into observation group and control group according to the random numerical table,with 35 cases in each group.The control group was treated with clotrimazole vaginal tablets,and the observation group was treated with live lactobacillus capsule based on the control group.Both groups were compared in terms of therapeutic effect,vaginal discharge index,occurrence of adverse reactions,symptom improvement time,occurrence of adverse maternal and infant outcomes,and recurrence.Results The total effective rate of the observation group was 85.71%,which was higher than that of 62.86%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-αand interleukin-6 in both groups were lower than those before treatment in this group;the levels of tumor necrosis factor-αof(14.36±4.01)ng/ml and interleukin-6 of(26.11±7.22)ng/L in the observation group were lower than those of(20.11±6.00)ng/ml and(38.45±6.99)ng/L in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 8.57%,which was lower than that of 28.57%in the control group,and the difference was statistically significant(P<0.05).The improvement time of pruritus,burning pain and abnormal secretion in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse maternal and infant outcomes in the observation group was 5.71%,which was lower than that of 25.71%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combined use of clotrimazole vaginal tablets and live lactobacillus capsules for VVC during pregnancy has an ideal therapeutic effect and is

关 键 词：妊娠期 外阴阴道假丝酵母菌病 克霉唑阴道片 乳杆菌活菌胶囊 阴道分泌物 母婴结局 复发 

分 类 号：R711.31[医药卫生—妇产科学]