生化指标、肿瘤标志物检验在胸腹腔积液诊断中的应用价值分析  

Analysis of the application value of biochemical indicators and tumor marker test in the diagnosis of pleural and peritoneal effusion

作　　者：朱顺强 ZHU Shun-qiang(Laboratory Department,Xianyou County General Hospital,Putian 351200,China)

机构地区：[1]福建省莆田市仙游县总医院检验科,351200

出　　处：《中国现代药物应用》2023年第15期73-76,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨在胸腹腔积液患者临床诊断中生化指标、肿瘤标志物检验的应用价值。方法105例胸腹腔积液患者,将手术病理确诊良性胸腹腔积液患者60例作为良性组,确诊恶性胸腹腔积液患者45例作为恶性组。两组患者术前均行生化指标与肿瘤标志物检验。对比两组患者生化指标[腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)、总蛋白(TP)、葡萄糖(GLU)]、肿瘤标志物[癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、甲胎蛋白(AFP)]水平,分析生化指标、肿瘤标志物单一检验以及联合检验的诊断效能。结果恶性组患者LDH(372.52±12.42)U/L、TP(46.25±4.32)g/L、GLU(7.43±1.44)mmol/L高于良性组的(94.52±8.78)U/L、(19.05±2.21)g/L、(4.12±1.12)mmol/L,ADA(8.43±1.18)U/L低于良性组的(16.25±2.05)U/L,差异具有统计学意义(P<0.05)。恶性组患者CEA、CA125、CA19-9、AFP水平分别为(198.85±15.21)μg/L、(1430.25±31.52)U/ml、(130.54±10.52)U/L、(402.25±15.87)ng/ml,均高于良性组的(4.21±1.05)μg/L、(600.85±11.54)U/ml、(12.32±1.42)U/L、(6.87±1.25)ng/ml,差异具有统计学意义(P<0.05)。联合检验敏感性、特异性、准确性均高于ADA、LDH、TP、GLU及CEA、CA125、CA19-9、AFP单一指标检验,差异具有统计学意义(P<0.05)。结论在胸腹腔积液患者的临床诊断中检验生化指标与肿瘤标志物具有较高的诊断价值,可通过生化指标与肿瘤标志物水平鉴别良、恶性,为临床医生制定治疗方案提供指导意义,建议临床推广并广泛应用。Objective To discuss the application value of biochemical indicators and tumor marker test in the diagnosis of pleural and peritoneal effusion.Methods Among 105 patients with pleural and peritoneal effusion,60 patients with benign pleural and peritoneal effusion confirmed by surgery and pathology were included in the benign group;45 patients with malignant pleural and peritoneal effusion were confirmed and included in the malignant group.All patients were tested with biochemical indicators and tumor markers before surgery.The biochemical indicators[adenosine deaminase(ADA),lactate dehydrogenase(LDH),total protein(TP),glucose(GLU)]and tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9),alpha-fetoprotein(AFP)]of benign and malignant pleural and peritoneal effusion were compared,and the diagnostic efficiency of single detection of biochemical indicators,tumor markers and combined detection were analyzed.Results Malignant group had LDH of(372.52±12.42)U/L,TP of(46.25±4.32)g/L and GLU of(7.43±1.44)mmol/L,which were higher than those of(94.52±8.78)U/L,(19.05±2.21)g/L and(4.12±1.12)mmol/L in benign group;ADA of(8.43±1.18)U/L in malignant group was lower than that of(16.25±2.05)U/L in benign group;the differences were statistically significant(P<0.05).In malignant group,CEA,CA125,CA19-9 and AFP levels were(198.85±15.21)μg/L,(1430.25±31.52)U/ml,(130.54±10.52)U/L,and(402.25±15.87)ng/ml,which were higher than those of(4.21±1.05)μg/L,(600.85±11.54)U/ml,(12.32±1.42)U/L,and(6.87±1.25)ng/ml in benign group,and the differences were statistically significant(P<0.05).The sensitivity,specificity and accuracy of the combined detection were higher than those of single detection of ADA,LDH,TP,GLU,CEA,CA125,CA19-9 and AFP,and the differences were statistically significant(P<0.05).Conclusion The detection of biochemical indicators and tumor markers in the clinical diagnosis of patients with pleural and peritoneal effusion has high diagnostic value.It can differe

关 键 词：胸腹腔积液 良性 恶性 生化指标 肿瘤标志物 诊断价值 

分 类 号：R561.3[医药卫生—呼吸系统] R57[医药卫生—内科学]