贝前列素钠结合前列地尔治疗对老年早期糖尿病肾病患者LAP、PCX及NF-κB活性的影响  

Effect of beraprost sodium combined with alprostadil treatment on LAP,PCX and NF-κB activity in elderly patients with early diabetic nephropathy

作　　者：吕秀娟[1] 陈新[1] 王艳[1] 逄琳 曹清红 LYU Xiu-juan;CHEN Xin;WANG Yan(Department of Geriatrics,Shenyang Fourth People's Hospital,Shenyang 110031,China)

机构地区：[1]沈阳市第四人民医院老年医学科,110031

出　　处：《中国现代药物应用》2023年第15期113-116,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究贝前列素钠联合前列地尔治疗对老年早期糖尿病肾病患者亮氨酸氨基肽酶(LAP)、足细胞标记蛋白(PCX)、核因子κB(NF-κB)活性情况。方法88例老年早期糖尿病肾病患者,依据随机数字表法分为对照组和观察组,各44例。对照组予以前列地尔静脉滴注治疗,观察组应用贝前列素钠口服联合前列地尔静脉滴注治疗。比较两组患者治疗效果、不良反应发生情况以及治疗前后肾功能指标[LAP、PCX、NF-κB、血肌酐(Scr)、尿素氮(BUN)、尿蛋白排泄率(UAER)]、炎症因子[肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)、超敏C反应蛋白(hs-CRP)]水平。结果观察组治疗总有效率97.73%高于对照组的84.09%,差异具有统计学意义(χ^(2)=4.950,P=0.026<0.05)。治疗后,观察组患者LAP(9.42±2.10)U/L、PCX(1.59±0.38)mg/ml、NF-κB(233.03±48.70)pg/ml、Scr(64.98±9.25)μmol/L、BUN(4.06±1.30)mmol/L、UAER(57.06±7.87)μg/min均低于对照组的(11.02±2.67)U/L、(2.67±0.49)mg/ml、(301.76±41.08)pg/ml、(81.16±9.78)μmol/L、(4.78±1.21)mmol/L、(81.00±9.63)μg/min,差异均具有统计学意义(P<0.05)。治疗后,观察组患者TNF-α(26.85±4.79)ng/L、IL-6(15.12±3.27)ng/L、hs-CRP(3.59±1.02)mg/L均低于对照组的(29.40±5.20)ng/L、(17.49±3.48)ng/L、(4.33±1.00)mg/L,差异均具有统计学意义(P<0.05)。两组患者治疗期间未见不良反应。结论在对老年早期糖尿病肾病患者的治疗中,应用前列地尔+贝前列素钠治疗,可提升治疗效果,减轻患者肾功能损伤。Objective To investigate the effect of beraprost sodium combined with alprostadil treatment on leucine aminopeptidase(LAP),podocalyxin(PCX)and nuclear factorκB(NF-κB)activity in elderly patients with early diabetic nephropathy.Methods A total of 88 elderly patients with early diabetic nephropathy were divided into control group and observation group according to the random numerical table,with 44 cases in each group.The control group was treated with intravenous infusion of alprostadil,and the observation group was treated with oral administration of beraprost sodium and intravenous infusion of alprostadil.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions,renal function indexes[LAP,PCX,NF-κB,blood creatinine(Scr),blood urea nitrogen(BUN),urinary albumin excretion rate(UAER)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)]level before and after treatment.Results The total effective rate of 97.73%in the observation group was higher than that of 84.09%in the control group,and the differences were statistically significant(χ^(2)=4.950,P=0.026<0.05).After treatment,the observation group had LAP of(9.42±2.10)U/L,PCX of(1.59±0.38)mg/ml,NF-κB of(233.03±48.70)pg/ml,Scr of(64.98±9.25)μmol/L,BUN of(4.06±1.30)mmol/L,and UAER of(57.06±7.87)μg/min,which were lower than those of(11.02±2.67)U/L,(2.67±0.49)mg/ml,(301.76±41.08)pg/ml,(81.16±9.78)μmol/L,(4.78±1.21)mmol/L,and(81.00±9.63)μg/min in the control group,and the differences were statistically significant(P<0.05).After treatment,the observation group had TNF-αof(26.85±4.79)ng/L,IL-6 of(15.12±3.27)ng/L,and hs-CRP of(3.59±1.02)mg/L,which were lower than those of(29.40±5.20)ng/L,(17.49±3.48)ng/L,and(4.33±1.00)mg/L in the control group,and the differences were statistically significant(P<0.05).No adverse reactions were observed in both groups during treatment.Conclusion In the treatment of elderly patients with early diabetic nephropathy,the a

关 键 词：老年早期糖尿病肾病 前列地尔 贝前列素钠 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]