叶酸缺乏对脑梗死责任病灶分布特征影响  

Effect of folic acid deficiency on the distribution of responsible lesions in cerebralinfarction

作　　者：余爱勇 彭亮 YU Aiyong;PENG Liang(Department of Neurology,Shanghai Songjiang District Central Hospital,Shanghai 201699,China;Department of Laboratory,Shanghai Songjiang District Central Hospital,Shanghai 201699,China)

机构地区：[1]上海市松江区中心医院[上海交通大学医学院附属松江医院(筹)]神经内科,上海201699 [2]上海市松江区中心医院[上海交通大学医学院附属松江医院(筹)]检验科,上海201699

出　　处：《中国现代医生》2023年第23期16-20,共5页China Modern Doctor

基　　金：上海市松江区科学技术攻关项目(22SJKJGG74)。

摘　　要：目的 研究叶酸水平降低合并脑梗死患者颅内梗死灶分布特征。方法 选取2018年10月至2022年7月在上海市松江区中心医院住院的脑梗死患者336例作为研究对象,根据叶酸水平分为叶酸降低组(n=165)和叶酸正常组(n=171)。比较两组患者实验室检查指标水平和脑梗死病灶分布的特点。结果 与叶酸正常组相比,叶酸降低组的同型半胱氨酸(homocysteine,Hcy)和游离甲状腺素(free thyroxine,FT4)水平均显著升高(P<0.05),分布于岛叶和放射冠的脑梗死病灶数量均显著增加(P<0.05)。两组分布于其他部位的脑梗死病灶数量比较,差异均无统计学意义(P>0.05)。经二元非条件Logistic回归分析,分布于岛叶和放射冠的梗死灶是叶酸降低的影响因素(P<0.05)。结论 叶酸水平降低对脑梗死病灶的分布可能存在影响,责任病灶主要集中在岛叶和放射冠。Objective To study the characteristics of intracranial lesions in patients with reduced folic acid levels and cerebral infarction.Methods A total of 336 patients with cerebral infarction who were hospitalized at Shanghai Songjiang District Central Hospital from October 2018 to July 2022 were selected and divided into a reduced folic acid group(n=165),and a normal folic acid group(n=171)based on their folic acid levels.The characteristics of laboratory examination and distribution of cerebral infarction lesions were compared between the two groups.Results Compared with the folic acid normal group,the folic acid reduced group had significantly higher homocysteine(Hcy)and free thyroxine(FT4)levels(P<0.05),and the number of cerebral infarct foci distributed in the insula and radiocorona were significantly increased(P<0.05).Compared with the number of cerebral infarction lesions distributed in other parts of the brain in both groups,the difference was not statistically significant(P>0.05).According to binary unconditional Logistic regression analysis,the infarct foci distributed in the insula and corona radiata were the influencing factors for folic acid reduction(P<0.05).Conclusion The decrease in folic acid levels may have an impact on the distribution of cerebral infarction lesions,with the responsible lesions mainly concentrated in the insula and coronal radiation.

关 键 词：叶酸 脑梗死 岛叶 放射冠 病变部位 

分 类 号：R587.1[医药卫生—内分泌]