阿奇霉素治疗移植后闭塞性细支气管炎的Meta分析  

Meta-analysis of azithromycin in the treatment of posttransplant occlusive bronchitis

作　　者：涂金伟[1] 苏艳艳 丁媛[1] TU Jinwei;SU Yanyan;DING Yuan(Department of Child Health Care,Children′s Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disease/China International Science and Technology Cooperation Base of Child development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院儿童保健科/儿童发育疾病研究教育部重点实验室/国家儿童健康与疾病临床医学研究中心/儿童发育重大疾病国家国际科技合作基地/儿童感染免疫重庆市重点实验室,400014重庆市 [2]郑州大学附属儿童医院,郑州市450053

出　　处：《临床合理用药杂志》2023年第23期11-15,共5页Chinese Journal of Clinical Rational Drug Use

基　　金：国家儿童健康与疾病临床医学研究中心儿童医疗保障创新研究示范基地项目(NCRCCHD-2019-HP-10)。

摘　　要：目的 系统分析阿奇霉素(AZI)治疗移植后闭塞性细支气管炎(BO)的效果。方法 检索PubMed、Cochrane Central Register of Controlled Trials、Embase、International Trial Registers、中国生物医学文献数据库、中国知网、万方数据库及维普数据库,检索时间从建库至2019年6月29日。两名研究人员独立筛选、审查和提取研究数据。使用STATA V.12.0进行统计学分析。结果 共纳入7项研究,356例移植后BO患者在AZI治疗后随访3~4个月,AZI组与非AZI组的第1秒用力呼气容积差异无统计学意义(WMD=-0.08,95%CI-0.13~-0.03,P=0.128),异质性不显著(I^(2)=39.5%)。亚组分析后RCT组、LT组提示2组有显著性差异(WMD=-0.13,95%CI-0.26~0.01,P=0.009;WMD=-0.08,95%CI-0.13~-0.02,P=0.004)。结论 AZI可能会改善移植后BO患者的肺功能,但还需进一步的研究证实此结论。Objective To analyze the effects of azithromycin(AZI)in the treatment of post-transplant bronchiolitis obliterans(BO)syndrome.Methods Retrieved PubMed,Cochrane Central Register of Controlled Trials,Embase,International Trial Registers,China Biomedical Literature Database,China National Knowledge Infrastructure,Wanfang Database and VIP Database from establishment to June 29,2019.Two researchers independently screened,reviewed and extracted research data.Perform statistical analysis using STATA V.12.0.Results A total of 7 studies were included,and 356 post transplant BO patients were followed up for 3~4 months after AZI treatment,there was no significant difference in forced expiratory volume at the first second between the AZI group and the non AZI group(WMD=-0.08,95%CI-0.13~-0.03,P=0.128),and heterogeneity was not significant(I^(2)=39.5%).After subgroup analysis,the RCT group and LT group showed significant differences between the two groups(WMD=-0.13,95%CI-0.26~0.01,P=0.009;WMD=-0.08,95%CI-0.13~-0.02,P=0.004).Conclusion AZI can improve lung function in post transplant BO patients,but further research is needed to confirm this conclusion.

关 键 词：闭塞性毛细支气管炎 阿奇霉素 造血干细胞移植 肺移植 META分析 

分 类 号：R562.21[医药卫生—呼吸系统]