孕晚期妊娠期高血压疾病患者止凝血参数与妊娠不良结局的相关性分析  

Correlation Analysis of Anticoagulation Parameters and Adverse Pregnancy Outcomes in Patients with Hypertensive Diseases in Late Pregnancy

作　　者：王国增[1] 王新[1] 李丽[1] 朱丽莉[1] 鲁煜红 朱潮旭 孙国宗 刘志强 WANG Guozeng;WANG Xin;LI Li(Zhuozhou City Hospital,Hebei Zhuozhou 072750,China)

机构地区：[1]河北省涿州市医院,河北涿州072750

出　　处：《河北医学》2023年第8期1344-1348,共5页Hebei Medicine

基　　金：河北省保定市科技局2021年科研课题项目,(编号:2141ZF174)。

摘　　要：目的:分析妊娠期高血压疾病患者止凝血参数变化与疾病严重程度以及不良妊娠结局之间的关系。方法:回顾选取2019年5月至2021年5月晚孕期妊高症住院患者199例为研究组:妊娠期高血压55例,子痫前期75例,重度子痫前期69例,同期年龄孕周匹配的健康孕妇59例为对照组。统计分析研究组各亚组止凝血相关参数变化与病情相关性和不良妊娠结局率。结果:妊娠期高血压组与对照组比较9项参数差异有统计学意义(P<0.05,P<0.01),子痫前期和重度子痫前期的活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)与对照组比较差异有统计学意义(P<0.05,P<0.01),Spearman显示FIB与其成正相关(P<0.01),MPV、APTT、TT、PLT、PCT与其成负相关(P<0.01),随着病情加重不良妊娠结局率增加,P<0.01,差异有统计学意义。结论:FIB、MPV、APTT、TT、PLT对于病情严重程度和不良结局具有潜在预测价值。Objective:To analyze the relationship between the changes of coagulation parameters and the severity of the disease and adverse pregnancy outcomes in patients with pregnancy induced hypertension disease(PIH).Methods:A total of 199 hospitalized patients with pregnancy induced hypertension in late pregnancy from May 2019 to May 2021 were retrospectively selected as the study group:55 cases of pregnancy induced hypertension,75 cases of pre eclampsia,69 cases of severe pre eclampsia,and 59 healthy pregnant women of the same age and week as the control group.The anticoagulation related parameters of each group and the adverse pregnancy outcome rate of the study group were statistically analyzed.Results:There were significant difference in 9 parameters between the hypertensive group during pregnancy and the control group(P<0.05,P<0.01),and there were significant difference in activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT),platelet count(PLT),mean platelet volume(MPV),and platelet hematocrit(PCT)between preeclampsia and severe preeclampsia and the control group(P<0.05,P<0.01).Spearman showed that FIB was positively correlated with them(P<0.01),MPV,APTT,TT,PLT,PCT were negatively correlated with them(P<0.01).With the aggravation of the disease,the adverse pregnancy outcome rate increased,P<0.01,and the difference was statistically significant.Conclusion:FIB,MPV,APTT,TT and PLT have potential predictive value for disease severity and adverse outcome.

关 键 词：妊娠期高血压疾病 止凝血参数 不良妊娠结局 相关性 

分 类 号：R714.246[医药卫生—妇产科学]