度洛西汀联合普瑞巴林对纤维肌痛综合征患者的临床疗效分析  

Clinical Efficacy Analysis of Duloxetine Combined with Pregabalin in the Treatment of Fibromyalgia Syndrome

作　　者：卢晓静 周志安[1] 边树伟[1] 邢晓芳 周桂荣[1] 王银华 竹琳 孙志欣 LU Xiaojing;ZHOU Zhi'an;BIAN Shuwei(Chengde Center Hospital,Hebei Chengde 067000,China)

机构地区：[1]河北省承德市中心医院全科医学科,河北承德067000

出　　处：《河北医学》2023年第8期1393-1397,共5页Hebei Medicine

基　　金：河北省承德市科学技术研究与发展项目,(编号:202109A017)。

摘　　要：目的:研究度洛西汀配合普瑞巴林治疗纤维肌痛综合征对改善患者疼痛症状和心理障碍的临床效果。方法:采取前瞻性研究方法,选取2020年6月至2022年6月由我院收治的120例纤维肌痛综合征患者进行研究,按随机性原则以1∶1比例分组,两组患者均给予普瑞巴林,观察组患者同时配合度洛西汀治疗,治疗时间均为6个月。比较两组患者的治疗效果、疼痛情况、负面情绪、睡眠、疲乏情况以及安全性之间的差异。结果:对照组和观察组治疗前的VAS评分组间比较差异无统计学意义(P>0.05),治疗后两组均明显减小,且治疗后各时间点观察组患者的VAS评分相比较对照组均明显减小(P<0.05),对照组和观察组治疗前的HAMA、HAMD评分组间比较差异无统计学意义(P>0.05),治疗后两组均明显减小,观察组患者的HAMA、HAMD评分降低程度显著高于对照组,观察组患者的治疗总有效率(95.00%)显著高于对照组(83.33%);对照组和观察组治疗前的PSQI评分、FSS评分组间比较差异无统计学意义(P>0.05),治疗后两组均明显减小,观察组患者的PSQI评分、FSS评分的变化程度显著高于对照组。两组患者治疗过程中各类不良反应发生率比较差异无统计学意义(P>0.05)。结论:纤维肌痛综合征采用度洛西汀联合普瑞巴林治疗,患者的疼痛情况、睡眠质量以及心理状况得到显著的改善,治疗效果较好。Objective:To study the clinical effect of duloxetine combined with pregabalin in the treatment of fibromyalgia syndrome on improving pain symptoms and psychological disorders of patients.Methods:In this prospective study,120 patients with fibromyalgia syndrome who were treated in our hospital from June 2020 to June 2022 were selected as research subjects.All patients were treated with pregabalin,and patients in the observation group were treated with duloxetine on this basis,and both groups were treated for 6 months.Differences in treatment outcomes,pain,negative emotions,sleep,fatigue,and safety were compared between the two groups.Results:The comparison of VAS scores between the control group and the observation group before treatment was statistically insignificant(P>0.05),and significantly decreased after treatment in both groups,and VAS scores in the observation group were significantly decreased at each time point after treatment compared with the control group(P<0.05).Statistically,there was no significant difference in HAMA and HAMD scores between the control group and the observation group before treatment(P>0.05).After treatment,the HAMA and HAMD scores in the observation group were significantly lower than those in the control group.The total effective rate of observation group(95.00%)was significantly higher than that of control group(83.33%).The comparison of PSQI score and FSS score between the control group and the observation group before treatment was statistically insignificant(P>0.05),and the two groups were significantly reduced after treatment.The change degree of PSQI score and FSS score in the observation group was significantly higher than that in the control group.There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion:When duloxetine combined with pregabalin was used to treat fibromyalgia syndrome,the pain,sleep quality and psychological status of the patients were significantly improved,and the therapeutic effe

关 键 词：纤维肌痛综合征 度洛西汀 普瑞巴林 睡眠质量 负面情绪 

分 类 号：R593.2[医药卫生—内科学]