中药多糖防治心血管疾病作用机制的研究进展  

Research progress on mechanism of traditional Chinese medicine polysaccharides in prevention and treatment of cardiovascular diseases

作　　者：郭靖文 付志飞 詹家国 冷玲 杨文志 王启隆 黎瑞巧 GUO Jing-wen;FU Zhi-fei;ZHAN Jia-guo;LENG Ling;YANG Wen-zhi;WANG Qi-long;LI Rui-qiao(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component Traditional Chinese Medicine,Tianjin 301617,China;Haihe Laboratory of Modern Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中医药研究院,天津301617 [2]组分中药国家重点实验室,天津301617 [3]现代中医药海河实验室,天津301617

出　　处：《现代药物与临床》2023年第7期1779-1785,共7页Drugs & Clinic

基　　金：国家重点研发计划(2022YFC3501800);国家自然科学基金资助项目(81973624);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202203)。

摘　　要：心血管疾病是危害人们健康的最主要的疾病之一。中药多糖可改善心肌缺血再灌注损伤、心肌梗死、动脉粥样硬化、心肌肥厚等多种心血管疾病,其保护机制为通过激活或抑制核因子-κB、磷脂酰肌醇3-激酶/蛋白激酶B、内质网应激、核因子E2相关因子2等多种信号通路,进而发挥抗氧化应激、抗炎、抗内质网应激、抗细胞凋亡和调节能量代谢紊乱作用来实现对心血管疾病的保护。总结了中药多糖防治心血管疾病的作用机制,以期为预防和治疗心血管疾病提供参考。Cardiovascular disease is one of major diseases endangering people's health.Traditional Chinese medicine polysaccharides can improve myocardial ischemia reperfusion injury,myocardial infarction,atherosclerosis,myocardial hypertrophy,and other cardiovascular diseases.The protective mechanism of traditional Chinese medicine polysaccharides on cardiovascular disease is through regulating NF-κB,Nrf2,PI3K/Akt,and other signaling pathways,and then play the role of anti-oxidative stress,antiinflammation,anti-endoplasmic reticulum stress,anti-apoptosis,and relieve energy metabolism disorder to achieve.This article summarized the mechanism of Chinese herbal polysaccharides in preventing and treating cardiovascular disease,hoping to provide reference for Chinese herbal polysaccharides in prevention and treatment of cardiovascular disease.

关 键 词：中药多糖 心血管疾病 氧化应激 抗炎 内质网应激 细胞凋亡 能量代谢紊乱 

分 类 号：R285.5[医药卫生—中药学]