他汀类药物抗肿瘤作用机制的研究进展  

Research progress on anti-tumor mechanism of statins

作　　者：曹志豪 金鹏耀 曾扬杰 任晓东 王举波[2] CAO Zhi-hao;JIN Peng-yao;ZENG Yang-jie;REN Xiao-dong;WANG Ju-bo(Medical College,Guizhou University,Guiyang 550025,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]贵州大学医学院,贵州贵阳550025 [2]中国药科大学药学院,江苏南京210009

出　　处：《现代药物与临床》2023年第7期1798-1804,共7页Drugs & Clinic

基　　金：贵州大学引进人才科研项目(贵大人基合字(2020)76号)。

摘　　要：他汀类药物属于3-羟基-3-甲基戊二酸单酰辅酶A还原酶抑制剂,近年来大量的临床研究显示,他汀类药物也具备抗肿瘤作用。他汀类药物可以通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、抑制肿瘤细胞侵袭和迁移、抗肿瘤血管生成、增强抗肿瘤免疫等发挥抗肿瘤作用。因此总结了他汀类药物的抗肿瘤作用机制,期望为他汀类药物进一步应用于肿瘤的治疗提供科学依据和理论支撑。Statins are classified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)reductase.In recent years,a large number of clinical studies have shown that statins also have anti-tumor effects.Statins have anti-tumor effects by inhibiting tumor cell proliferation,promoting tumor cell apoptosis,inhibiting tumor cell invasion and migration,resisting tumor angiogenesis,and enhancing anti-tumor immunity.This article summarizes the anti-tumor mechanism of statins,hoping to provide scientific basis and theoretical support for the further application of statins in treatment of tumors.

关 键 词：他汀类药物 细胞增殖 细胞凋亡 细胞侵袭 细胞迁移 血管生成 抗肿瘤免疫 

分 类 号：R965[医药卫生—药理学] R979.1[医药卫生—药学]